Academic Journal
Angelica keiskei water extract Mitigates Age-Associated Physiological Decline in Mice
| Title: | Angelica keiskei water extract Mitigates Age-Associated Physiological Decline in Mice |
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| Authors: | Huan Liu, Gang Wei, Tongxing Wang, Yunlong Hou, Bin Hou, Xiaoyan Li, Chao Wang, Mingzhe Sun, Min Su, Zhifang Guo, Lu Wang, Ning Kang, Mengnan Li, Zhenhua Jia |
| Source: | Redox Report, Vol 29, Iss 1 (2024) |
| Publisher Information: | Taylor & Francis Group, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Pathology LCC:Biology (General) |
| Subject Terms: | Oxidative stress, nature products, healthy aging, valvular pigmentation, network pharmacology, molecular docking, Pathology, RB1-214, Biology (General), QH301-705.5 |
| More Details: | Objective Angelica keiskei is a medicinal and edible plant that has been reported to possess potent antioxidant properties in several in vitro models, but its effectiveness on naturally aging organisms is still lacking. This study explores the antioxidant and health-promoting effects of Angelica keiskei in naturally aging mice.Methods We treated 48-week-old mice with Angelica keiskei water extract (AKWE) 30 days, and measured indicators related to aging and antioxidants. In addition, we conducted network pharmacology analysis, component-target molecular docking, real-time PCR, and MTS assays to investigate relevant factors.Results The results indicated that administration of AKWE to mice led to decrease blood glucose levels, improve muscle fiber structure, muscle strength, gait stability, and increase levels of glutathione and superoxide dismutase in serum. Additionally, it decreased pigmentation of the heart tissues. Angelica keiskei combats oxidative stress by regulating multiple redox signaling pathways, and its ingredients Coumarin and Flavonoids have the potential to bind to SIRT3 and SIRT5.Conclusions Our findings indicated the potential of Angelica keiskei as a safe and effective dietary supplement to combat aging and revealed the broad prospects of medicinal and edible plants for addressing aging and age-related chronic diseases. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 13510002 1743-2928 1351-0002 |
| Relation: | https://doaj.org/toc/1351-0002; https://doaj.org/toc/1743-2928 |
| DOI: | 10.1080/13510002.2024.2305036 |
| Access URL: | https://doaj.org/article/cfde74f39da84ec49c153d4060fd35ae |
| Accession Number: | edsdoj.fde74f39da84ec49c153d4060fd35ae |
| Database: | Directory of Open Access Journals |
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| ISSN: | 13510002 17432928 |
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| DOI: | 10.1080/13510002.2024.2305036 |
| Published in: | Redox Report |
| Language: | English |