Bibliographic Details
| Title: |
The Role of Small-Bowel Capsule Endoscopy in the Diagnostic Algorithm of Complicated Perianal Disease |
| Authors: |
Irit Avni-Biron, Ervin Toth, Jacob E. Ollech, Artur Nemeth, Gabriele Wurm Johansson, Hagai Schweinstein, Reuma Yehuda Margalit, Uri Kopylov, Iris Dotan, Henit Yanai |
| Source: |
Diagnostics, Vol 14, Iss 16, p 1733 (2024) |
| Publisher Information: |
MDPI AG, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Medicine (General) |
| Subject Terms: |
capsule endoscopy, perianal Crohn’s disease, diagnosis, algorithm, fecal calprotectin, Medicine (General), R5-920 |
| More Details: |
Introduction: Complicated perianal disease (cPD) may be the sole presentation of Crohn’s disease (CD). The role of small-bowel capsule endoscopy (SBCE) in the diagnostic algorithm of cPD is unclear. We aimed to evaluate the role of SBCE as a diagnostic tool, in patients with cPD, after a negative standard workup for CD. Methods: A multicenter, retrospective, cross-sectional study, in patients with cPD, and negative standard workup for CD (ileocolonoscopy and cross-sectional imaging), who underwent SBCE for suspected CD. Demographics, biomarkers, and the Lewis Score (LS) were recorded and analyzed. An LS ≥ 135 was considered a positive SBCE for diagnosing CD. Results: Ninety-one patients were included: 65 (71.4%) males; median age: 37 (29–51) years; cPD duration: 25.1 (12.5–66.1) months. Positive SBCE: 24/91 (26.4%) patients. Fecal calprotectin (FC) positively correlated with LS (r = 0.81; p < 0.001). FC levels of 100 µg/g and 50 µg/g had a sensitivity of only 40% and 55% to rule out small-bowel CD, with a negative predictive value (NPV) of only 76% and 80%, respectively. Conclusions: SBCE contributed to CD diagnosis in a quarter of patients with cPD after a negative standard workup. FC levels correlated with the degree of inflammation defined by the LS. However, the NPV of FC was low, suggesting that SBCE should be considered for patients with cPD even after a negative standard workup. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2075-4418 |
| Relation: |
https://www.mdpi.com/2075-4418/14/16/1733; https://doaj.org/toc/2075-4418 |
| DOI: |
10.3390/diagnostics14161733 |
| Access URL: |
https://doaj.org/article/fd9c9713fb494a6e9a931efa8fe9ae7a |
| Accession Number: |
edsdoj.fd9c9713fb494a6e9a931efa8fe9ae7a |
| Database: |
Directory of Open Access Journals |
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