Clinical and Laboratory Manifestation of Gastrointestinal Involvement in MIS-C: A Single-Center Observational Study
| Title: | Clinical and Laboratory Manifestation of Gastrointestinal Involvement in MIS-C: A Single-Center Observational Study |
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| Authors: | Snezhina Lazova, Latchezar Tomov, Dimitrina Miteva, Iren Tzotcheva, Stamatios Priftis, Tsvetelina Velikova |
| Source: | Gastroenterology Insights, Vol 14, Iss 2, Pp 236-248 (2023) |
| Publisher Information: | MDPI AG, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Diseases of the digestive system. Gastroenterology |
| Subject Terms: | Multisystem Inflammatory Syndrome in Children (MIS-C), SARS-CoV-2, COVID-19, children, gastrointestinal involvement, abdominal pain, Diseases of the digestive system. Gastroenterology, RC799-869 |
| More Details: | Background: Digestive symptoms and gastrointestinal issues in children with coronavirus 2019 disease (COVID-19) and Multisystem Inflammatory Syndrome in Children (MIS-C) are commonly reported in pediatric studies from different countries. Our retrospective observational study aimed to summarize the main digestive symptoms and objective data on gastrointestinal involvement in children with MIS-C. Methods: We present the clinical, laboratory, and imaging data of 51 children with MIS-C hospitalized in a single center from 25 November 2020 to 24 April 2021, focusing on gastrointestinal involvement. Results: A total of 46/51 children (90.2%) reported at least one abdominal symptom (abdominal pain (86%, N = 44), vomiting, nausea, diarrhea), predominantly at presentation. Most children were older than 5 years (N = 40, 78%), predominated by the male sex (N = 37, 72.5%), and with a mean age of 8.82 ± 4.16 years. We found a tendency for lymphopenia, neutrophilia, and higher levels of CRP, d-dimer, and ferritin in MIS-C patients with abdominal pain (R-squared 0.188, F-statistic vs. constant model: 11.9, p-value = 0.00122, 20% explanation of variation with p = 0.001). We found a statistically significant linear relationship (regression) between neutrophile percentage (NEU%) and hospital stay and a tendency for elevated transaminases to be more frequent in older children (27.3% under 5 years and 65% over 5 years; p = 0.0583). We found no significant associations between digestive symptoms and age or the predominant SARS-CoV-2 variant. Conclusions: Most of our MIS-C patients presented with abdominal pain, usually along with other GI symptoms, which could be applied in clinical practice to MIS-C in children visiting the emergency room with abdominal pain and evidence of recent COVID-19 contact or infection. Further information from larger cohorts of MIS-C patients is needed to better understand the epidemiology of gastrointestinal involvement in these patients. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 14020017 2036-7422 2036-7414 |
| Relation: | https://www.mdpi.com/2036-7422/14/2/17; https://doaj.org/toc/2036-7414; https://doaj.org/toc/2036-7422 |
| DOI: | 10.3390/gastroent14020017 |
| Access URL: | https://doaj.org/article/fd57d99a640849e0b865834f37f1ac58 |
| Accession Number: | edsdoj.fd57d99a640849e0b865834f37f1ac58 |
| Database: | Directory of Open Access Journals |
| ISSN: | 14020017 20367422 20367414 |
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| DOI: | 10.3390/gastroent14020017 |
| Published in: | Gastroenterology Insights |
| Language: | English |