Academic Journal
The Association among Hypothalamic Subnits, Gonadotropic and Sex Hormone Plasmas Levels in Alzheimer’s Disease
| Title: | The Association among Hypothalamic Subnits, Gonadotropic and Sex Hormone Plasmas Levels in Alzheimer’s Disease |
|---|---|
| Authors: | Edward Ofori, Anamaria Solis, Nahid Punjani, on behalf of the Alzheimer’s Disease Neuroimaging Initiative |
| Source: | Brain Sciences, Vol 14, Iss 3, p 276 (2024) |
| Publisher Information: | MDPI AG, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| Subject Terms: | Alzheimer’s disease, hypothalamic–pituitary–gonadal axis, neurodegeneration, cognitive status, gonadotropic hormones, sex hormones, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| More Details: | This study investigates the sex-specific role of the Hypothalamic–Pituitary–Gonadal axis in Alzheimer’s disease progression, utilizing ADNI1 data for 493 individuals, analyzing plasma levels of gonadotropic and sex hormones, and examining neurodegeneration-related brain structures. We assessed plasma levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), progesterone (P4), and testosterone (T), along with volumetric measures of the hippocampus, entorhinal cortex, and hypothalamic subunits, to explore their correlation with Alzheimer’s disease markers across different cognitive statuses and sexes. Significant cognitive status effects were observed for all volumetric measures, with a distinct sex-by-cognitive status interaction for hypothalamic volume, indicating a decrease in males but not in females across cognitive impairment stages. Regression analyses showed specific hypothalamic subunit volume related to hormone levels, accounting for up to approximately 40% of the variance (p < 0.05). The findings highlight sex differences in neurodegeneration and hormonal regulation, suggesting potential for personalized treatments and advancing the understanding of Alzheimer’s disease etiology. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 14030276 2076-3425 |
| Relation: | https://www.mdpi.com/2076-3425/14/3/276; https://doaj.org/toc/2076-3425 |
| DOI: | 10.3390/brainsci14030276 |
| Access URL: | https://doaj.org/article/fd54ceaa63e449b6bb8924c514f0802c |
| Accession Number: | edsdoj.fd54ceaa63e449b6bb8924c514f0802c |
| Database: | Directory of Open Access Journals |
| Full text is not displayed to guests. | Login for full access. |
| ISSN: | 14030276 20763425 |
|---|---|
| DOI: | 10.3390/brainsci14030276 |
| Published in: | Brain Sciences |
| Language: | English |