Bibliographic Details
| Title: |
Behind the developing brains and beating hearts of stem cell-derived embryo models |
| Authors: |
Gianluca Amadei, David M. Glover |
| Source: |
Open Biology, Vol 13, Iss 1 (2023) |
| Publisher Information: |
The Royal Society, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Biology (General) |
| Subject Terms: |
stem cells, embryo models, haematopoiesis, Biology (General), QH301-705.5 |
| More Details: |
Studies over the past decade have shown how stem cells representing embryonic and extra-embryonic tissues of the mouse can self-assemble in the culture dish to recapitulate an astonishing part of early embryonic development. A systematic analysis has demonstrated how pluripotent embryonic stem cells can be induced to behave like the implanting epiblast; how they can interact with trophectoderm stem cells to form a patterned structure resembling the implanting embryo prior to gastrulation; and how the third stem cell type—extra-embryonic endoderm cells—can be incorporated to generate structures that undergo the cell movements and gene expression patterns of gastrulation. Moreover, such stem cell-derived embryo models can proceed to neurulation and establish progenitors for all parts of the brain and neural tube, somites, beating heart structures and gut tube. They develop within extra-embryonic yolk sacs that initiate haematopoiesis. Here we trace this journey of discovery. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2046-2441 |
| Relation: |
https://doaj.org/toc/2046-2441 |
| DOI: |
10.1098/rsob.220325 |
| Access URL: |
https://doaj.org/article/fd42485fb1c1499db7e7ca02298a4baa |
| Accession Number: |
edsdoj.fd42485fb1c1499db7e7ca02298a4baa |
| Database: |
Directory of Open Access Journals |
