Bibliographic Details
| Title: |
Dapagliflozin reduces pulmonary vascular damage and susceptibility to atrial fibrillation in right heart disease |
| Authors: |
Chang Dai, Bin Kong, Wei Shuai, Zheng Xiao, Tianyou Qin, Jin Fang, Yang Gong, Jun Zhu, Qi Liu, Hui Fu, Hong Meng, He Huang |
| Source: |
ESC Heart Failure, Vol 10, Iss 1, Pp 578-593 (2023) |
| Publisher Information: |
Wiley, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Diseases of the circulatory (Cardiovascular) system |
| Subject Terms: |
Dapagliflozin, Atrial fibrillation, Right heart disease, Pulmonary arterial hypertension, Monocrotaline, Electrocardiography, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| More Details: |
Abstract Aims Sodium‐glucose cotransporter 2 inhibitors (SGLT2is) have made considerable progress in the field of heart failure, but their application in arrhythmia remains to be in‐depth. Right heart disease (RHD) often leads to right heart dysfunction and is associated with atrial fibrillation (AF). Here, we explored the possible electrophysiologic effect of dapagliflozin (a type of SGLT2is) in the development of AF in rats with RHD. Methods and results Rats in the experimental group were intraperitoneally injected with a single dose of 60 mg/kg monocrotaline (MCT group, n = 32) on the first day of the experiment, whereas rats in the control group were injected with vehicle (CTL group, n = 32). Rats in the treatment subgroup were treated with dapagliflozin solution orally (MCT + DAPA and CTL + DAPA groups) for a total of 4 weeks, whereas rats in the rest of subgroups were given sterile drinking water. After 4 weeks, echocardiography demonstrated that MCT group rats developed obvious pulmonary arterial hypertension and right heart dysfunction. In addition, there were also obvious inflammatory infiltration, fibrosis, and muscularization in right atrial and pulmonary arteries. The P‐wave duration (17.00 ± 0.53 ms, vs. 14.43 ± 0.57 ms in CTL; 14.00 ± 0.65 ms in CTL + DAPA; 14.57 ± 0.65 ms in MCT + DAPA; P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2055-5822 |
| Relation: |
https://doaj.org/toc/2055-5822 |
| DOI: |
10.1002/ehf2.14169 |
| Access URL: |
https://doaj.org/article/fd3fb5d946204bc8b671cdb105e21b69 |
| Accession Number: |
edsdoj.fd3fb5d946204bc8b671cdb105e21b69 |
| Database: |
Directory of Open Access Journals |
