Bibliographic Details
| Title: |
Antihyperlipidemic effect of bread fortified with potato peel powder against Triton X-100-induced hyperlipidemia in male albino rats |
| Authors: |
Osama I.A. Soltan, Hanaa S.S. Gazwi, Amany E. Ragab, Magda E. Mahmoud, Ferial M.N. Fudllalah, Mesfer M. Alqahtani, Abdulrahman Alasmari, Hesham S. Ghazzawy, Dalia M. Hikal |
| Source: |
Journal of Functional Foods, Vol 108, Iss , Pp 105725- (2023) |
| Publisher Information: |
Elsevier, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Nutrition. Foods and food supply |
| Subject Terms: |
Bread, Potato peels, Triton X-100, AMPKα signaling pathway, Nutrition. Foods and food supply, TX341-641 |
| More Details: |
The present investigation aimed to improve the nutritional and healthy values and evaluate the influence of bread fortified with dried potato peels (BPP) on Triton X-100-induced hyperlipidemia in male albino rats. The findings demonstrated that BPP lowered hepatic triglycerides and total cholesterol while increasing high-density lipoprotein (HDL-C). BPP exhibited potential lipid-lowering and hepatoprotective actions that were generated by the reduction of oxidative damage and preservation of the non-enzymatic and enzymatic antioxidant systems compromised by hyperlipidemic condition. Furthermore, BPP considerably enhanced the mRNA expression of AMPKα (AMP-activated protein kinase-alpha), suppressed the expression of fatty acid synthase (FAS) and acetyl-CoA carboxylase alpha (ACCα), and decreased the mRNA expression of the adipogenic transcription factor SREBP-1c (sterol regulatory element-binding protein-1c), which are essential regulators of hepatocyte lipid metabolism. A histopathological assessment of the liver confirmed the results. In conclusion, this investigation revealed a positive impact of bread fortified with BPP therapy in preventing hyperlipidemia. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1756-4646 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1756464623003250; https://doaj.org/toc/1756-4646 |
| DOI: |
10.1016/j.jff.2023.105725 |
| Access URL: |
https://doaj.org/article/fceb6c4dfc484b72b150157442c5c208 |
| Accession Number: |
edsdoj.fceb6c4dfc484b72b150157442c5c208 |
| Database: |
Directory of Open Access Journals |
