Academic Journal
Acoustic Radiation Forced Impulse of the Liver and the Spleen, Combined with Spleen Dimension and Platelet Count in New Ratio Scores, Identifies High-Risk Esophageal Varices in Well-Compensated Cirrhotic Patients
| Title: | Acoustic Radiation Forced Impulse of the Liver and the Spleen, Combined with Spleen Dimension and Platelet Count in New Ratio Scores, Identifies High-Risk Esophageal Varices in Well-Compensated Cirrhotic Patients |
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| Authors: | Antonio F. M. Vainieri, Elisa Brando, Antonio De Vincentis, Giulia Di Pasquale, Valentina Flagiello, Paolo Gallo, Francesca Barone, Teresa Massaro Cenere, Evelyn Di Matteo, Antonio Picardi, Giovanni Galati |
| Source: | Diagnostics, Vol 14, Iss 7, p 685 (2024) |
| Publisher Information: | MDPI AG, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Medicine (General) |
| Subject Terms: | ARFI, acoustic radiation forced impulse, platelet count, spleen, esophageal varices, Medicine (General), R5-920 |
| More Details: | Acoustic radiation forced impulse (ARFI) is an integrated ultrasound method, measuring stiffness by point shear wave elastography. To evaluate the diagnostic performance of the ARFI of the liver and the spleen, combined with spleen dimension and platelet count, in predicting high-risk esophageal varices (HRVs) in cirrhotic patients, a prospective and cross-sectional study was conducted between February 2017 and February 2021. The following ratio scores were calculated based on ARFI measurements: ALSDP (ARFI Liver–Spleen Diameter-to-Platelet Ratio Score), ASSDP (ARFI Spleen–Spleen Diameter-to-Platelet Ratio Score), ASSAP (ARFI Spleen–Spleen Area-to-Platelet Ratio Score), and ALSAP (ARFI Liver–Spleen Area-to-Platelet Ratio Score). In 100 enrolled subjects, spleen ARFI, ASSDP, and ASSAP were significantly associated with HRVs in the prospective short- and long-term follow-ups and in the cross-sectional study (p < 0.05), while ALSDP and ALSAP were associated with HRVs only in the prospective long-term follow-up and cross-sectional study (p< 0.05). ASSAP was the best ARFI ratio score for HRVs at the long-term follow-up [value of area under curve (AUC) = 0.88], although all the ARFI ratio scores performed better than individual liver and spleen ARFI (AUC > 0.7). In our study, ARFI ratio scores can predict, in well-compensated cirrhotic patients, the risk of developing HVRs in short- and long-term periods. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 14070685 2075-4418 |
| Relation: | https://www.mdpi.com/2075-4418/14/7/685; https://doaj.org/toc/2075-4418 |
| DOI: | 10.3390/diagnostics14070685 |
| Access URL: | https://doaj.org/article/fc9e7197cb824582bde750d6be3f7074 |
| Accession Number: | edsdoj.fc9e7197cb824582bde750d6be3f7074 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 14070685 20754418 |
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| DOI: | 10.3390/diagnostics14070685 |
| Published in: | Diagnostics |
| Language: | English |