Bibliographic Details
| Title: |
RHOA signaling defects result in impaired axon guidance in iPSC-derived neurons from patients with tuberous sclerosis complex |
| Authors: |
Timothy S. Catlett, Massimo M. Onesto, Alec J. McCann, Sarah K. Rempel, Jennifer Glass, David N. Franz, Timothy M. Gómez |
| Source: |
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021) |
| Publisher Information: |
Nature Portfolio, 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Science |
| Subject Terms: |
Science |
| More Details: |
Patients with Tuberous Sclerosis Complex (TSC) show aberrant wiring of neuronal connections. Here, the authors generate iPSC-derived neurons from patients with TSC. TSC2 +/− neurons show impaired mTOR-independent RhoA signaling-mediated axon guidance. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-021-22770-4 |
| Access URL: |
https://doaj.org/article/fc9b5914dcfa4ad4b2da1ea8ef8bcc7c |
| Accession Number: |
edsdoj.fc9b5914dcfa4ad4b2da1ea8ef8bcc7c |
| Database: |
Directory of Open Access Journals |
