Academic Journal
Kidney function, proteinuria and breast arterial calcification in women without clinical cardiovascular disease: The MINERVA study.
| Title: | Kidney function, proteinuria and breast arterial calcification in women without clinical cardiovascular disease: The MINERVA study. |
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| Authors: | Rishi V Parikh, Carlos Iribarren, Catherine Lee, Tory Levine-Hall, Thida C Tan, Gabriela Sanchez, Huanjun Ding, Fatemeh Azamian Bidgoli, Sabee Molloi, Alan S Go |
| Source: | PLoS ONE, Vol 14, Iss 1, p e0210973 (2019) |
| Publisher Information: | Public Library of Science (PLoS), 2019. |
| Publication Year: | 2019 |
| Collection: | LCC:Medicine LCC:Science |
| Subject Terms: | Medicine, Science |
| More Details: | BackgroundBreast arterial calcification (BAC) may be a predictor of cardiovascular events and is highly prevalent in persons with end-stage kidney disease. However, few studies to date have examined the association between mild-to-moderate kidney function and proteinuria with BAC.MethodsWe prospectively enrolled women with no prior cardiovascular disease aged 60 to 79 years undergoing mammography screening at Kaiser Permanente Northern California between 10/24/2012 and 2/13/2015. Urine albumin-to-creatinine ratio (uACR), along with specific laboratory, demographic, and medical data, were measured at the baseline visit. Baseline estimated glomerular filtration rate (eGFR), medication history, and other comorbidities were identified from self-report and/or electronic medical records. BAC presence and gradation (mass) was measured by digital quantification of full-field mammograms.ResultsAmong 3,507 participants, 24.5% were aged ≥70 years, 63.5% were white, 7.5% had eGFR 0 mg) was 27.9%. Neither uACR ≥30 mg/g nor uACR ≥300 were significantly associated with BAC in crude or multivariable analyses. Reduced eGFR was associated with BAC in univariate analyses (odds ratio 1.53, 95% CI: 1.18-2.00), but the association was no longer significant after adjustment for potential confounders. Results were similar in various sensitivity analyses that used different BAC thresholds or analytic approaches.ConclusionsAmong women without cardiovascular disease undergoing mammography screening, reduced eGFR and albuminuria were not significantly associated with BAC. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1932-6203 |
| Relation: | https://doaj.org/toc/1932-6203 |
| DOI: | 10.1371/journal.pone.0210973 |
| Access URL: | https://doaj.org/article/fc804f235f7e41789396036d1c07e6f2 |
| Accession Number: | edsdoj.fc804f235f7e41789396036d1c07e6f2 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 19326203 |
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| DOI: | 10.1371/journal.pone.0210973 |
| Published in: | PLoS ONE |
| Language: | English |