Bibliographic Details
| Title: |
Structural insights into the clustering and activation of Tie2 receptor mediated by Tie2 agonistic antibody |
| Authors: |
Gyunghee Jo, Jeomil Bae, Ho Jeong Hong, Ah-reum Han, Do-Kyun Kim, Seon Pyo Hong, Jung A Kim, Sangkyu Lee, Gou Young Koh, Ho Min Kim |
| Source: |
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021) |
| Publisher Information: |
Nature Portfolio, 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Science |
| Subject Terms: |
Science |
| More Details: |
Angiopoietin (Angpt)-Tie receptor 2 (Tie2) regulates vascular stability and is thus a potential therapeutic target in vascular diseases. Here, the authors report a Tie2-agonistic antibody which targets a site distinct from the Angpt 1-binding site and which influences Tie2 clustering and activation in an Angpt2 inhibition-resistant manner. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-021-26620-1 |
| Access URL: |
https://doaj.org/article/fc69bcd280cf4fe0bfa69e52efbb0a96 |
| Accession Number: |
edsdoj.fc69bcd280cf4fe0bfa69e52efbb0a96 |
| Database: |
Directory of Open Access Journals |
