Bibliographic Details
| Title: |
SARS-CoV-2 mRNA Vaccine Response in People Living with HIV According to CD4 Count and CD4/CD8 Ratio |
| Authors: |
Alessandra Vergori, Alessandro Tavelli, Giulia Matusali, Anna Maria Azzini, Matteo Augello, Valentina Mazzotta, Giovanni Francesco Pellicanò, Andrea Costantini, Antonio Cascio, Andrea De Vito, Lorenzo Marconi, Elda Righi, Assunta Sartor, Carmela Pinnetti, Fabrizio Maggi, Francesca Bai, Simone Lanini, Stefania Piconi, Gabriel Levy Hara, Giulia Marchetti, Maddalena Giannella, Evelina Tacconelli, Antonella d’Arminio Monforte, Andrea Antinori, Alessandro Cozzi-Lepri, on behalf of the Vax-ICONA-ORCHESTRA Study |
| Source: |
Vaccines, Vol 11, Iss 11, p 1664 (2023) |
| Publisher Information: |
MDPI AG, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Medicine |
| Subject Terms: |
HIV, PLWH, CD4 count, CD4/CD8 ratio, SARS-CoV-2 mRNA vaccine, humoral response, Medicine |
| More Details: |
Background: Our aim was to estimate the rates of not achieving a robust/above-average humoral response to the COVID-19 mRNA vaccine in people living with HIV (PLWH) who received ≥2 doses and to investigate the role of the CD4 and CD4/CD8 ratio in predicting the humoral response. Methods: We evaluated the humoral anti-SARS-CoV-2 response 1-month after the second and third doses of COVID-19 mRNA vaccine as a proportion of not achieving a robust/above-average response using two criteria: (i) a humoral threshold identified as a correlate of protection against SARS-CoV-2 ( 200 cells/mm3 and a ratio > 0.6. Conclusions: A robust humoral response after a booster dose has not been reached by 50% of PLWH with CD4 < 200 cells mm3. In the absence of a validated correlate of protections in the Omicron era, the CD4 count remains the most solid marker to guide vaccination campaigns in PLWH. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2076-393X |
| Relation: |
https://www.mdpi.com/2076-393X/11/11/1664; https://doaj.org/toc/2076-393X |
| DOI: |
10.3390/vaccines11111664 |
| Access URL: |
https://doaj.org/article/dfc19fae67334a88af68e14c0363fa5b |
| Accession Number: |
edsdoj.fc19fae67334a88af68e14c0363fa5b |
| Database: |
Directory of Open Access Journals |
