Academic Journal
Associations of modifiable and non-modifiable risk factors with cognitive functions – a prospective, population-based, 17 years follow-up study of 3,229 individuals
| Title: | Associations of modifiable and non-modifiable risk factors with cognitive functions – a prospective, population-based, 17 years follow-up study of 3,229 individuals |
|---|---|
| Authors: | Isabelle Glans, Katarina Nägga, Anna-Märta Gustavsson, Erik Stomrud, Peter M Nilsson, Olle Melander, Oskar Hansson, Sebastian Palmqvist |
| Source: | Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-12 (2024) |
| Publisher Information: | BMC, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Neurosciences. Biological psychiatry. Neuropsychiatry LCC:Neurology. Diseases of the nervous system |
| Subject Terms: | Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429 |
| More Details: | Abstract Background Although several cardiovascular, demographic, genetic and lifestyle factors have been associated with cognitive function, little is known about what type of cognitive impairment they are associated with. The aim was to examine the associations between different risk factors and future memory and attention/executive functions, and their interaction with APOE genotype. Methods Participants from a large, prospective, population-based, Swedish study were included (n = 3,229). Linear regression models were used to examine baseline hypertension, body mass index (BMI), long-term glucose levels (HbA1c), different lipid levels, physical activity, alcohol consumption, smoking, education, APOE genotype, age and sex. All models were adjusted for follow-up time and basic demographics, and, in a second step, all significant predictors were included to examine independent effects. Follow-up outcomes were memory and attention/executive functions. Results The mean age at baseline was 56.1 (SD 5.7) years and 59.7% were women. The mean follow-up time was 17.4 (range 14.3–20.8) years. When examining independent effects, APOE ε4 genotype(p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1758-9193 |
| Relation: | https://doaj.org/toc/1758-9193 |
| DOI: | 10.1186/s13195-024-01497-6 |
| Access URL: | https://doaj.org/article/fbd1cc4a0a784acbaa25cf7ce5a947a7 |
| Accession Number: | edsdoj.fbd1cc4a0a784acbaa25cf7ce5a947a7 |
| Database: | Directory of Open Access Journals |
| Full text is not displayed to guests. | Login for full access. |
| ISSN: | 17589193 |
|---|---|
| DOI: | 10.1186/s13195-024-01497-6 |
| Published in: | Alzheimer’s Research & Therapy |
| Language: | English |