Disposition Kinetics of Taxanes in Peritoneal Dissemination
| Title: | Disposition Kinetics of Taxanes in Peritoneal Dissemination |
|---|---|
| Authors: | Ken'ichi Miyamoto, Tsutomu Shimada, Kazuki Sawamoto, Yoshimichi Sai, Yutaka Yonemura |
| Source: | Gastroenterology Research and Practice, Vol 2012 (2012) |
| Publisher Information: | Hindawi Limited, 2012. |
| Publication Year: | 2012 |
| Collection: | LCC:Diseases of the digestive system. Gastroenterology |
| Subject Terms: | Diseases of the digestive system. Gastroenterology, RC799-869 |
| More Details: | Treatment of cancers in the abdominal cavity, such as peritoneal dissemination, is difficult, but in principle intraperitoneal administration of anticancer drugs is expected to be preferable to systemic administration. Taxane anticancer drugs are used to treat gastric cancer patients with peritoneal dissemination. They are administered as micellar preparations, Taxol and Taxotere, which consist of paclitaxel in Cremophor EL (crEL) and docetaxel in Polysorbate-80 (PS-80), respectively. In this paper we review the disposition kinetics of taxane anticancer drugs after intraperitoneal administration in peritoneal dissemination patients and animal models and also discuss the effect of the surfactant vehicle on the behavior of taxanes. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1687-6121 1687-630X |
| Relation: | https://doaj.org/toc/1687-6121; https://doaj.org/toc/1687-630X |
| DOI: | 10.1155/2012/963403 |
| Access URL: | https://doaj.org/article/fb8e02e1980e42d7842b6347b00f05d8 |
| Accession Number: | edsdoj.fb8e02e1980e42d7842b6347b00f05d8 |
| Database: | Directory of Open Access Journals |
| ISSN: | 16876121 1687630X |
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| DOI: | 10.1155/2012/963403 |
| Published in: | Gastroenterology Research and Practice |
| Language: | English |