Bibliographic Details
| Title: |
Biosynthesis of Gold Nanoparticles and Its Effect against Pseudomonas aeruginosa |
| Authors: |
Syed Ghazanfar Ali, Mohammad Jalal, Hilal Ahmad, Khalid Umar, Akil Ahmad, Mohammed B. Alshammari, Haris Manzoor Khan |
| Source: |
Molecules, Vol 27, Iss 24, p 8685 (2022) |
| Publisher Information: |
MDPI AG, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Organic chemistry |
| Subject Terms: |
biofilm, GC-MS, gold nanoparticles, Pseudomonas aeruginosa, pyocyanin, Organic chemistry, QD241-441 |
| More Details: |
Antimicrobial resistance has posed a serious health concern worldwide, which is mainly due to the excessive use of antibiotics. In this study, gold nanoparticles synthesized from the plant Tinospora cordifolia were used against multidrug-resistant Pseudomonas aeruginosa. The active components involved in the reduction and stabilization of gold nanoparticles were revealed by gas chromatography–mass spectrophotometry(GC-MS) of the stem extract of Tinospora cordifolia. Gold nanoparticles (TG-AuNPs) were effective against P. aeruginosa at different concentrations (50,100, and 150 µg/mL). TG-AuNPs effectively reduced the pyocyanin level by 63.1% in PAO1 and by 68.7% in clinical isolates at 150 µg/mL; similarly, swarming and swimming motilities decreased by 53.1% and 53.8% for PAO1 and 66.6% and 52.8% in clinical isolates, respectively. Biofilm production was also reduced, and at a maximum concentration of 150 µg/mL of TG-AuNPs a 59.09% reduction inPAO1 and 64.7% reduction in clinical isolates were observed. Lower concentrations of TG-AuNPs (100 and 50 µg/mL) also reduced the pyocyanin, biofilm, swarming, and swimming. Phenotypically, the downregulation of exopolysaccharide secretion from P. aeruginosa due to TG-AuNPs was observed on Congo red agar plates |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1420-3049 |
| Relation: |
https://www.mdpi.com/1420-3049/27/24/8685; https://doaj.org/toc/1420-3049 |
| DOI: |
10.3390/molecules27248685 |
| Access URL: |
https://doaj.org/article/fb766154c5d341379d6926573d59f080 |
| Accession Number: |
edsdoj.fb766154c5d341379d6926573d59f080 |
| Database: |
Directory of Open Access Journals |
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