Limited Effect of 60-Days Strict Head Down Tilt Bed Rest on Vascular Aging
| Title: | Limited Effect of 60-Days Strict Head Down Tilt Bed Rest on Vascular Aging |
|---|---|
| Authors: | Stefan Möstl, Stefan Orter, Fabian Hoffmann, Martin Bachler, Bernhard Hametner, Siegfried Wassertheurer, Jérémy Rabineau, Edwin Mulder, Bernd Johannes, Jens Jordan, Jens Tank |
| Source: | Frontiers in Physiology, Vol 12 (2021) |
| Publisher Information: | Frontiers Media S.A., 2021. |
| Publication Year: | 2021 |
| Collection: | LCC:Physiology |
| Subject Terms: | pre-ejection period, pulse wave arrival time, pulse wave velocity, artificial gravity, AGBRESA, arterial stiffness, Physiology, QP1-981 |
| More Details: | BackgroundCardiovascular risk may be increased in astronauts after long term space flights based on biomarkers indicating premature vascular aging. We tested the hypothesis that 60 days of strict 6° head down tilt bed rest (HDTBR), an established space analog, promotes vascular stiffening and that artificial gravity training ameliorates the response.MethodsWe studied 24 healthy participants (8 women, 24–55 years, BMI = 24.3 ± 2.1 kg/m2) before and at the end of 60 days HDTBR. 16 subjects were assigned to daily artificial gravity. We applied echocardiography to measure stroke volume and isovolumetric contraction time (ICT), calculated aortic compliance (stroke volume/aortic pulse pressure), and assessed aortic distensibility by MRI. Furthermore, we measured brachial-femoral pulse wave velocity (bfPWV) and pulse wave arrival times (PAT) in different vascular beds by blood pressure cuffs and photoplethysmography. We corrected PAT for ICT (cPAT).ResultsIn the pooled sample, diastolic blood pressure (+8 ± 7 mmHg, p < 0.001), heart rate (+7 ± 9 bpm, p = 0.002) and ICT (+8 ± 13 ms, p = 0.036) increased during HDTBR. Stroke volume decreased by 14 ± 15 ml (p = 0.001). bfPWV, aortic compliance, aortic distensibility and all cPAT remained unchanged. Aortic area tended to increase (p = 0.05). None of the parameters showed significant interaction between HDTBR and artificial gravity training.Conclusion60 days HDTBR, while producing cardiovascular deconditioning and cephalad fluid shifts akin to weightlessness, did not worsen vascular stiffness. Artificial gravity training did not modulate the response. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1664-042X |
| Relation: | https://www.frontiersin.org/articles/10.3389/fphys.2021.685473/full; https://doaj.org/toc/1664-042X |
| DOI: | 10.3389/fphys.2021.685473 |
| Access URL: | https://doaj.org/article/fb38c1d368b341baabb180b629549acf |
| Accession Number: | edsdoj.fb38c1d368b341baabb180b629549acf |
| Database: | Directory of Open Access Journals |
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| Items | – Name: Title Label: Title Group: Ti Data: Limited Effect of 60-Days Strict Head Down Tilt Bed Rest on Vascular Aging – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Stefan+Möstl%22">Stefan Möstl</searchLink><br /><searchLink fieldCode="AR" term="%22Stefan+Orter%22">Stefan Orter</searchLink><br /><searchLink fieldCode="AR" term="%22Fabian+Hoffmann%22">Fabian Hoffmann</searchLink><br /><searchLink fieldCode="AR" term="%22Martin+Bachler%22">Martin Bachler</searchLink><br /><searchLink fieldCode="AR" term="%22Bernhard+Hametner%22">Bernhard Hametner</searchLink><br /><searchLink fieldCode="AR" term="%22Siegfried+Wassertheurer%22">Siegfried Wassertheurer</searchLink><br /><searchLink fieldCode="AR" term="%22Jérémy+Rabineau%22">Jérémy Rabineau</searchLink><br /><searchLink fieldCode="AR" term="%22Edwin+Mulder%22">Edwin Mulder</searchLink><br /><searchLink fieldCode="AR" term="%22Bernd+Johannes%22">Bernd Johannes</searchLink><br /><searchLink fieldCode="AR" term="%22Jens+Jordan%22">Jens Jordan</searchLink><br /><searchLink fieldCode="AR" term="%22Jens+Tank%22">Jens Tank</searchLink> – Name: TitleSource Label: Source Group: Src Data: Frontiers in Physiology, Vol 12 (2021) – Name: Publisher Label: Publisher Information Group: PubInfo Data: Frontiers Media S.A., 2021. – Name: DatePubCY Label: Publication Year Group: Date Data: 2021 – Name: Subset Label: Collection Group: HoldingsInfo Data: LCC:Physiology – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22pre-ejection+period%22">pre-ejection period</searchLink><br /><searchLink fieldCode="DE" term="%22pulse+wave+arrival+time%22">pulse wave arrival time</searchLink><br /><searchLink fieldCode="DE" term="%22pulse+wave+velocity%22">pulse wave velocity</searchLink><br /><searchLink fieldCode="DE" term="%22artificial+gravity%22">artificial gravity</searchLink><br /><searchLink fieldCode="DE" term="%22AGBRESA%22">AGBRESA</searchLink><br /><searchLink fieldCode="DE" term="%22arterial+stiffness%22">arterial stiffness</searchLink><br /><searchLink fieldCode="DE" term="%22Physiology%22">Physiology</searchLink><br /><searchLink fieldCode="DE" term="%22QP1-981%22">QP1-981</searchLink> – Name: Abstract Label: Description Group: Ab Data: BackgroundCardiovascular risk may be increased in astronauts after long term space flights based on biomarkers indicating premature vascular aging. We tested the hypothesis that 60 days of strict 6° head down tilt bed rest (HDTBR), an established space analog, promotes vascular stiffening and that artificial gravity training ameliorates the response.MethodsWe studied 24 healthy participants (8 women, 24–55 years, BMI = 24.3 ± 2.1 kg/m2) before and at the end of 60 days HDTBR. 16 subjects were assigned to daily artificial gravity. We applied echocardiography to measure stroke volume and isovolumetric contraction time (ICT), calculated aortic compliance (stroke volume/aortic pulse pressure), and assessed aortic distensibility by MRI. Furthermore, we measured brachial-femoral pulse wave velocity (bfPWV) and pulse wave arrival times (PAT) in different vascular beds by blood pressure cuffs and photoplethysmography. We corrected PAT for ICT (cPAT).ResultsIn the pooled sample, diastolic blood pressure (+8 ± 7 mmHg, p < 0.001), heart rate (+7 ± 9 bpm, p = 0.002) and ICT (+8 ± 13 ms, p = 0.036) increased during HDTBR. Stroke volume decreased by 14 ± 15 ml (p = 0.001). bfPWV, aortic compliance, aortic distensibility and all cPAT remained unchanged. Aortic area tended to increase (p = 0.05). None of the parameters showed significant interaction between HDTBR and artificial gravity training.Conclusion60 days HDTBR, while producing cardiovascular deconditioning and cephalad fluid shifts akin to weightlessness, did not worsen vascular stiffness. Artificial gravity training did not modulate the response. – Name: TypeDocument Label: Document Type Group: TypDoc Data: article – Name: Format Label: File Description Group: SrcInfo Data: electronic resource – Name: Language Label: Language Group: Lang Data: English – Name: ISSN Label: ISSN Group: ISSN Data: 1664-042X – Name: NoteTitleSource Label: Relation Group: SrcInfo Data: https://www.frontiersin.org/articles/10.3389/fphys.2021.685473/full; https://doaj.org/toc/1664-042X – Name: DOI Label: DOI Group: ID Data: 10.3389/fphys.2021.685473 – Name: URL Label: Access URL Group: URL Data: <link linkTarget="URL" linkTerm="https://doaj.org/article/fb38c1d368b341baabb180b629549acf" linkWindow="_blank">https://doaj.org/article/fb38c1d368b341baabb180b629549acf</link> – Name: AN Label: Accession Number Group: ID Data: edsdoj.fb38c1d368b341baabb180b629549acf |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3389/fphys.2021.685473 Languages: – Text: English Subjects: – SubjectFull: pre-ejection period Type: general – SubjectFull: pulse wave arrival time Type: general – SubjectFull: pulse wave velocity Type: general – SubjectFull: artificial gravity Type: general – SubjectFull: AGBRESA Type: general – SubjectFull: arterial stiffness Type: general – SubjectFull: Physiology Type: general – SubjectFull: QP1-981 Type: general Titles: – TitleFull: Limited Effect of 60-Days Strict Head Down Tilt Bed Rest on Vascular Aging Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Stefan Möstl – PersonEntity: Name: NameFull: Stefan Orter – PersonEntity: Name: NameFull: Fabian Hoffmann – PersonEntity: Name: NameFull: Martin Bachler – PersonEntity: Name: NameFull: Bernhard Hametner – PersonEntity: Name: NameFull: Siegfried Wassertheurer – PersonEntity: Name: NameFull: Jérémy Rabineau – PersonEntity: Name: NameFull: Edwin Mulder – PersonEntity: Name: NameFull: Bernd Johannes – PersonEntity: Name: NameFull: Jens Jordan – PersonEntity: Name: NameFull: Jens Tank IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Type: published Y: 2021 Identifiers: – Type: issn-print Value: 1664042X Numbering: – Type: volume Value: 12 Titles: – TitleFull: Frontiers in Physiology Type: main |
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