Bibliographic Details
| Title: |
Analysis of chromatin organization and gene expression in T cells identifies functional genes for rheumatoid arthritis |
| Authors: |
Jing Yang, Amanda McGovern, Paul Martin, Kate Duffus, Xiangyu Ge, Peyman Zarrineh, Andrew P. Morris, Antony Adamson, Peter Fraser, Magnus Rattray, Stephen Eyre |
| Source: |
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020) |
| Publisher Information: |
Nature Portfolio, 2020. |
| Publication Year: |
2020 |
| Collection: |
LCC:Science |
| Subject Terms: |
Science |
| More Details: |
Although genome-wide association studies have identified genetic variation contributing to disease risk, assigning causal genes is challenging. Here, the authors generate ATAC-seq, Hi-C, Capture Hi-C and RNA-seq data in stimulated CD4+ T cells to identify functional enhancers and demonstrate interactions of expression quantitative trait loci with target genes in rheumatoid arthritis. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-020-18180-7 |
| Access URL: |
https://doaj.org/article/cfb2cf5b4bb44d5cacaff7677eed292d |
| Accession Number: |
edsdoj.fb2cf5b4bb44d5cacaff7677eed292d |
| Database: |
Directory of Open Access Journals |
