Real‐world outcomes of FOLFIRINOX vs gemcitabine and nab‐paclitaxel in advanced pancreatic cancer: A population‐based propensity score‐weighted analysis
| Title: | Real‐world outcomes of FOLFIRINOX vs gemcitabine and nab‐paclitaxel in advanced pancreatic cancer: A population‐based propensity score‐weighted analysis |
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| Authors: | Kelvin K. W. Chan, Helen Guo, Sierra Cheng, Jaclyn M. Beca, Ruby Redmond‐Misner, Wanrudee Isaranuwatchai, Lucy Qiao, Craig Earle, Scott R. Berry, James J. Biagi, Stephen Welch, Brandon M. Meyers, Nicole Mittmann, Natalie Coburn, Jessica Arias, Deborah Schwartz, Wei F. Dai, Scott Gavura, Robin McLeod, Erin D. Kennedy |
| Source: | Cancer Medicine, Vol 9, Iss 1, Pp 160-169 (2020) |
| Publisher Information: | Wiley, 2020. |
| Publication Year: | 2020 |
| Collection: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: | FOLFIRINOX, gemcitabine, outcomes, pancreatic cancer, real‐world evidence, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: | Abstract Background In Ontario, FOLFIRINOX (FFX) and gemcitabine + nab‐paclitaxel (GnP) have been publicly funded for first‐line unresectable locally advanced pancreatic cancer (uLAPC) or metastatic pancreatic cancer (mPC) since April 2015. We examined the real‐world effectiveness and safety of FFX vs GnP for advanced pancreatic cancer, and in uLAPC and mPC. Methods Patients receiving first‐line FFX or GnP from April 2015 to March 2017 were identified in the New Drug Funding Program database. Baseline characteristics and outcomes were obtained through the Ontario Cancer Registry and other population‐based databases. Overall survival (OS) was assessed using Kaplan‐Meier and weighted Cox proportional hazard models, weighted by the inverse propensity score adjusting for baseline characteristics. Weighted odds ratio (OR) for hospitalization and emergency department visits (EDV) were estimated from weighted logistic regression models. Results For 1130 patients (632 FFX, 498 GnP), crude median OS was 9.6 and 6.1 months for FFX and GnP, respectively. Weighted OS was improved for FFX vs GnP (HR = 0.77, 0.70‐0.85). Less frequent EDV and hospitalization were observed in FFX (EDV: 67.8%; Hospitalization: 49.2%) than GnP (EDV: 77.7%; Hospitalization: 59.3%). More frequent febrile neutropenia‐related hospitalization was observed in FFX (5.8%) than GnP (3.3%). Risk of EDV and hospitalization were significantly lower for FFX vs GnP (EDV: OR = 0.68, P = .0001; Hospitalization: OR = 0.76, P = .002), whereas the risk of febrile neutropenia‐related hospitalization was significantly higher (OR = 2.12, P = .001). Outcomes for uLAPC and mPC were similar. Conclusion In the real world, FFX had longer OS, less frequent all‐cause EDV and all‐cause hospitalization, but more febrile neutropenia‐related hospitalization compared to GnP. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2045-7634 31489184 |
| Relation: | https://doaj.org/toc/2045-7634 |
| DOI: | 10.1002/cam4.2705 |
| Access URL: | https://doaj.org/article/fad31489184a462b8ea666cc826aa71b |
| Accession Number: | edsdoj.fad31489184a462b8ea666cc826aa71b |
| Database: | Directory of Open Access Journals |
| ISSN: | 20457634 31489184 |
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| DOI: | 10.1002/cam4.2705 |
| Published in: | Cancer Medicine |
| Language: | English |