Academic Journal
Multi-therapeutic-activity selenium nanodot toward preventing brain injury and restoring neurobehavioral functions following hemorrhagic stroke
| Title: | Multi-therapeutic-activity selenium nanodot toward preventing brain injury and restoring neurobehavioral functions following hemorrhagic stroke |
|---|---|
| Authors: | Yibin Zhang, Xiaoyu Wang, Xuegang Niu, Haojie Wang, Yi Wu, Chunwang Li, Huimin Wang, Shen Lin, Dengliang Wang, Fuxin Lin, Peisen Yao, Yuanxiang Lin, Dezhi Kang, Bin Gao |
| Source: | Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-23 (2024) |
| Publisher Information: | BMC, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Biotechnology LCC:Medical technology |
| Subject Terms: | Multi-therapeutic-activity, Selenium nanodot, Hemorrhagic stroke, Prevent brain injury, Restorre neurobehavioral functions, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5 |
| More Details: | Abstract Intracerebral hemorrhage is a lethal cerebrovascular disease, and the inevitable secondary brain injury (SBI) is responsible for serious disability and death. Perfect therapeutic goal is to minimize SBI and restore neurobehavioral functions. Recently, neuroprotection is highlighted to reduce SBI, but it still faces “Neuronal survival but impaired functions” dilemma. Herein, this work further proposes a novel combinational therapeutic strategy of neuroprotection and neurogenesis toward this goal. However, appropriate therapeutic agents are rarely reported, and their discovery and development are urgently needed. Selenium participates in various physiological/pathological processes, which is hypothesized as a potential targeting molecule. To explore this effect, this work formulates an ultra-small selenium nanodot with a seleno-amino acid derived carbon dot domain and a hydrophilic PEG layer, surprisingly finding that it increases various selenoproteins levels at perihematomal region, to not only exert multiple neuroprotective roles at acute phase but promote neurogenesis and inhibit glial scar formation at recovery phase. At a safe dose, this combinational strategy effectively prevents SBI and recovers neurobehavioral functions to a normal level. Furthermore, its molecular mechanisms are revealed to broaden application scopes in other complex diseases. Graphical abstract |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1477-3155 |
| Relation: | https://doaj.org/toc/1477-3155 |
| DOI: | 10.1186/s12951-024-02847-0 |
| Access URL: | https://doaj.org/article/facdb35ef546465b83a535ead0bc682e |
| Accession Number: | edsdoj.facdb35ef546465b83a535ead0bc682e |
| Database: | Directory of Open Access Journals |
| Full text is not displayed to guests. | Login for full access. |
| ISSN: | 14773155 |
|---|---|
| DOI: | 10.1186/s12951-024-02847-0 |
| Published in: | Journal of Nanobiotechnology |
| Language: | English |