Bibliographic Details
| Title: |
LKB1 drives stasis and C/EBP-mediated reprogramming to an alveolar type II fate in lung cancer |
| Authors: |
Christopher W. Murray, Jennifer J. Brady, Mingqi Han, Hongchen Cai, Min K. Tsai, Sarah E. Pierce, Ran Cheng, Janos Demeter, David M. Feldser, Peter K. Jackson, David B. Shackelford, Monte M. Winslow |
| Source: |
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022) |
| Publisher Information: |
Nature Portfolio, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Science |
| Subject Terms: |
Science |
| More Details: |
LKB1 tumour suppressor gene is frequently mutated in lung adenocarcinoma. Here the authors show that in genetically engineered mouse models of lung cancer Lkb1 restoration induces growth arrest and drives neoplastic cells toward a more differentiated and less proliferative alveolar type II cell-like state via C/EBP-mediated reprogramming. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-022-28619-8 |
| Access URL: |
https://doaj.org/article/fac054136b674b659d92c440e9e9e2b2 |
| Accession Number: |
edsdoj.fac054136b674b659d92c440e9e9e2b2 |
| Database: |
Directory of Open Access Journals |
