Ketone monoester attenuates declines in cognitive performance and oxygen saturation during acute severe hypoxic exposure under resting conditions

Bibliographic Details
Title:	Ketone monoester attenuates declines in cognitive performance and oxygen saturation during acute severe hypoxic exposure under resting conditions
Authors:	Tyler S. McClure, Jeffrey Phillips, Andrew P. Koutnik, Kody Coleman, Ed Chappe, Gary R. Cutter, Brendan Egan, Todd Norell, Brianna J. Stubbs, Marcas M. Bamman, Dawn Kernagis
Source:	Experimental Physiology, Vol 109, Iss 10, Pp 1672-1682 (2024)
Publisher Information:	Wiley, 2024.
Publication Year:	2024
Collection:	LCC:Physiology
Subject Terms:	β‐hydroxybutyrate, code substitution, cognitive resilience, exogenous ketosis, Physiology, QP1-981
More Details:	Abstract Exogenous ketone supplements are a potential augmentation strategy for cognitive resilience during acute hypoxic exposure due to their capacity to attenuate the decline in oxygen (O2) availability, and by providing an alternative substrate for cerebral metabolism. Utilizing a single‐blind randomized crossover design, 16 male military personnel (age, 25.3 ± 2.4 year, body mass, 86.2 ± 9.3 kg) performed tests of cognitive performance at rest in three environments: room air (baseline), normoxia (20 min; 0 m; 20.9% O2) and hypoxia (20 min; 6096 m, 9.7% O2) using a reduced O2 breathing device (ROBD). (R)‐3‐Hydroxybutyl (R)‐3‐hydroxybutyrate (R‐BD R‐βHB) ketone monoester (KME; 650 mg/kg, split dose given at 30 min prior to each exposure) or taste‐matched placebo (PLA) was ingested prior to normoxia and hypoxic exposure. Blood R‐βHB and glucose concentrations, cognitive performance and O2 saturation (SpO2) were collected throughout. KME ingestion increased blood R‐βHB concentration, which was rapid and sustained (>4 mM 30 min post; P
Document Type:	article
File Description:	electronic resource
Language:	English
ISSN:	1469-445X 0958-0670
Relation:	https://doaj.org/toc/0958-0670; https://doaj.org/toc/1469-445X
DOI:	10.1113/EP091794
Access URL:	https://doaj.org/article/cfa9181a701f4a6cbd23af0e94ea2803
Accession Number:	edsdoj.fa9181a701f4a6cbd23af0e94ea2803
Database:	Directory of Open Access Journals

More Details
ISSN:	1469445X 09580670
DOI:	10.1113/EP091794
Published in:	Experimental Physiology
Language:	English