High incidence of catheter-associated urinary tract infections and related antibiotic resistance in two hospitals of different geographic regions of Sierra Leone: a prospective cohort study

Bibliographic Details
Title:	High incidence of catheter-associated urinary tract infections and related antibiotic resistance in two hospitals of different geographic regions of Sierra Leone: a prospective cohort study
Authors:	Sulaiman Lakoh, Le Yi, James B.W. Russell, Juling Zhang, Stephen Sevalie, Yongkun Zhao, Joseph Sam Kanu, Peng Liu, Sarah K. Conteh, Christine Ellen Elleanor Williams, Umu Barrie, Olukemi Adekanmbi, Darlinda F. Jiba, Matilda N. Kamara, Daniel Sesay, Gibrilla F. Deen, Joseph Chukwudi Okeibunor, George A. Yendewa, Xuejun Guo, Emmanuel Firima
Source:	BMC Research Notes, Vol 16, Iss 1, Pp 1-8 (2023)
Publisher Information:	BMC, 2023.
Publication Year:	2023
Collection:	LCC:Medicine LCC:Biology (General) LCC:Science (General)
Subject Terms:	Multidrug resistance organisms (MRO), Extended spectrum β-lactamase (ESBL)-producing Enterobacteriaceae, Catheter-associated urinary tract Infections (CAUTI), WHO priority pathogens, Carbapenem resistance Enterobacteriaceae (CRE), Medicine, Biology (General), QH301-705.5, Science (General), Q1-390
More Details:	Abstract Objective Catheter-associated urinary tract infections (CAUTI) are common worldwide, but due to limited resources, its actual burden in low-income countries is unknown. Currently, there are gaps in knowledge about CAUTI due to lack of surveillance activities in Sierra Leone. In this prospective cohort study, we aimed to determine the incidence of CAUTI and associated antibiotic resistance in two tertiary hospitals in different regions of Sierra Leone. Results The mean age of the 459 recruited patients was 48.8 years. The majority were females (236, 51.3%). Amongst the 196 (42.6%) catheterized patients, 29 (14.8%) developed CAUTI. Bacterial growth was reported in 32 (84%) patients. Escherichia coli (14, 23.7%), Klebsiella pneumoniae (10, 17.0%), and Klebsiella oxytoca (8, 13.6%) were the most common isolates. Most isolates were ESBL-producing Enterobacteriaceae (33, 56%) and WHO Priority 1 (Critical) pathogens (38, 71%). Resistance of K. pneumoniae, K. oxytoca, E. coli, and Proteus mirabilis was higher with the third-generation cephalosporins and penicillins but lower with carbapenems, piperacillin-tazobactam and amikacin. To reduce the high incidence of CAUTI and multi-drug resistance organisms, urgent action is needed to strengthen the microbiology diagnostic services and develop and implement catheter bundles that provide clear guidance for catheter insertion, care and removal.
Document Type:	article
File Description:	electronic resource
Language:	English
ISSN:	1756-0500
Relation:	https://doaj.org/toc/1756-0500
DOI:	10.1186/s13104-023-06591-w
Access URL:	https://doaj.org/article/fa1d669870714fd08de9e0597941471f
Accession Number:	edsdoj.fa1d669870714fd08de9e0597941471f
Database:	Directory of Open Access Journals

More Details
ISSN:	17560500
DOI:	10.1186/s13104-023-06591-w
Published in:	BMC Research Notes
Language:	English