Bibliographic Details
| Title: |
Interleukin-37: A Link Between COVID-19, Diabetes, and the Black Fungus |
| Authors: |
Sima Tokajian, Georgi Merhi, Charbel Al Khoury, Georges Nemer |
| Source: |
Frontiers in Microbiology, Vol 12 (2022) |
| Publisher Information: |
Frontiers Media S.A., 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Microbiology |
| Subject Terms: |
COVID-19, T2D, corticosteroids, mucormycosis, IL-37, Microbiology, QR1-502 |
| More Details: |
The COVID-19 pandemic involved millions of people and diabetes was identified as an associated comorbidity. Initiation of systemic corticosteroids in patients suffering from severe COVID-19 was associated with lower mortality. A surge of invasive fungal infections of the maxillofacial region, namely mucormycosis, was linked to a deadly infection known as black fungus. Black fungus, diabetes, corticosteroids, and coronavirus disease 2019 (COVID-19) all have a dysregulated immune response in common, which partly could also be attributed to interleukin 37 (IL-37). IL-37, a new cytokine of the IL-1 family, known for broadly reducing innate inflammation as well as acquired immune responses. The use of corticosteroids in diabetic COVID-19 patients, crowded hospitals, and lack of medical oxygen should be carefully considered to reduce COVID-associated secondary infections. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1664-302X |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fmicb.2021.788741/full; https://doaj.org/toc/1664-302X |
| DOI: |
10.3389/fmicb.2021.788741 |
| Access URL: |
https://doaj.org/article/f9e26655b41b40358701dcaedd36f62b |
| Accession Number: |
edsdoj.f9e26655b41b40358701dcaedd36f62b |
| Database: |
Directory of Open Access Journals |
