The inflammatory burden index is a superior systemic inflammation biomarker for the prognosis of non‐small cell lung cancer
| Title: | The inflammatory burden index is a superior systemic inflammation biomarker for the prognosis of non‐small cell lung cancer |
|---|---|
| Authors: | Hailun Xie, Guotian Ruan, Lishuang Wei, Li Deng, Qi Zhang, Yizhong Ge, Mengmeng Song, Xi Zhang, Shiqi Lin, Xiaoyue Liu, Ming Yang, Chunhua Song, Xiaowei Zhang, Hanping Shi |
| Source: | Journal of Cachexia, Sarcopenia and Muscle, Vol 14, Iss 2, Pp 869-878 (2023) |
| Publisher Information: | Wiley, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Diseases of the musculoskeletal system LCC:Human anatomy |
| Subject Terms: | Systemic inflammation, Biomarker, Prognosis, Cachexia, Expenses, Non‐small cell lung cancer, Diseases of the musculoskeletal system, RC925-935, Human anatomy, QM1-695 |
| More Details: | Abstract Background Systemic inflammation, the most representative tumour–host interaction, plays a crucial role in disease progression and prognosis in patients with non‐small cell lung cancer (NSCLC). Few studies have compared the performance of existing haematological systemic inflammation biomarkers in predicting the prognosis of NSCLC patients. The purpose of this study was to compare the prognostic value of existing systemic inflammation biomarkers and determine the optimal systemic inflammation biomarker in patients with NSCLC through a multicentre prospective study. Methods The predictive accuracy of systemic inflammation biomarkers for prognostic assessment in NSCLC was assessed using C‐statistics. Inter‐group differences in survival were assessed using the log‐rank test and visualized using the Kaplan–Meier method. A restricted cubic spline (RCS) curve was used to explore the association between the biomarkers and survival. Independent prognostic biomarkers for overall survival were determined using multivariable Cox proportional hazards regression analysis. Logistic regression analysis was used to determine independent predictors of 90‐day outcomes, length of hospitalization, hospitalization expenses and cachexia. Results The inflammatory burden index (IBI) had the highest C‐statistic for predicting the prognosis of patients with NSCLC, reaching 0.640 (0.617, 0.663). Patients with a high IBI had significantly worse outcomes than those with a low IBI (35.46% vs. 57.22%; log‐rank P |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2190-6009 2190-5991 |
| Relation: | https://doaj.org/toc/2190-5991; https://doaj.org/toc/2190-6009 |
| DOI: | 10.1002/jcsm.13199 |
| Access URL: | https://doaj.org/article/f96d5e80478f448daec801b3b93a03fa |
| Accession Number: | edsdoj.f96d5e80478f448daec801b3b93a03fa |
| Database: | Directory of Open Access Journals |
| ISSN: | 21906009 21905991 |
|---|---|
| DOI: | 10.1002/jcsm.13199 |
| Published in: | Journal of Cachexia, Sarcopenia and Muscle |
| Language: | English |