Bibliographic Details
| Title: |
Altered theta band and theta/beta ratio in mismatch negativity associate with treatment effect in schizophrenia with auditory hallucinations |
| Authors: |
Qian Guo, Zexin Zhao, Wenzheng Wang, Xiaonan Hu, Hao Hu, Yao Hu, Lihua Xu, Xu Liu, Xiaohua Liu, Guanjun Li, Zhongying Shi, Jijun Wang |
| Source: |
Schizophrenia Research: Cognition, Vol 40, Iss , Pp 100344- (2025) |
| Publisher Information: |
Elsevier, 2025. |
| Publication Year: |
2025 |
| Collection: |
LCC:Neurology. Diseases of the nervous system |
| Subject Terms: |
Mismatch negative wave, Schizophrenia, Auditory hallucination, Neural oscillation, And treatment effect, Neurology. Diseases of the nervous system, RC346-429 |
| More Details: |
Evidence suggests that attenuated mismatch negative (MMN) waves have a close link to auditory verbal hallucinations (AVH) and their clinical outcomes, especially impaired neural oscillations such as θ, β representing attentional control. In current study, thirty patients with schizophrenia and AVH (SZ) and twenty-nine healthy controls (HC) underwent multi-feature MMN paradigm measurements including frequency and duration deviant stimuli (fMMN and dMMN). Clinical symptoms and MMN paradigm were followed up among SZ group after 8-week treatment. Results demonstrated that hallucinating patients exhibited attenuated dMMN amplitudes across Fz (p = 0.010), F1 (p = 0.020) and F2 (p = 0.014) electrodes, which were trendily recovered after treatment. Meanwhile, θ band and TBR at frontal fMMN and right temporal dMMN were significantly reduced in SZs. After treatment, SZs showed reduced scores of Hoffman's Auditory Hallucinations Rating Scale (AHRS), with a remarkable recovery in right temporal TBR of dMMN (p = 0.042) and a trending change in frontal TBR of fMMN (p = 0.090). The β band was decreased in dMMN (p = 0.035) by time. Additionally, P3 scores of Positive and Negative Syndrome Scale (PANSS) were negatively correlated with θ band of fMMN at baseline. Baseline scores of AHRS negatively predicted changes of dMMN amplitude after treatment, and changes of β band in left temporal dMMN predicted the reduction in scores of PANSS negative scale. These findings supported that deficits in θ oscillation and TBR during auditory attention process were crucial to clinical progression of schizophrenia with AVH. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2215-0013 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2215001325000010; https://doaj.org/toc/2215-0013 |
| DOI: |
10.1016/j.scog.2025.100344 |
| Access URL: |
https://doaj.org/article/df96bf5765914d1eb7aa56f36512b091 |
| Accession Number: |
edsdoj.f96bf5765914d1eb7aa56f36512b091 |
| Database: |
Directory of Open Access Journals |
