The complex relationship of exposure to new Plasmodium infections and incidence of clinical malaria in Papua New Guinea
| Title: | The complex relationship of exposure to new Plasmodium infections and incidence of clinical malaria in Papua New Guinea |
|---|---|
| Authors: | Natalie E Hofmann, Stephan Karl, Rahel Wampfler, Benson Kiniboro, Albina Teliki, Jonah Iga, Andreea Waltmann, Inoni Betuela, Ingrid Felger, Leanne J Robinson, Ivo Mueller |
| Source: | eLife, Vol 6 (2017) |
| Publisher Information: | eLife Sciences Publications Ltd, 2017. |
| Publication Year: | 2017 |
| Collection: | LCC:Medicine LCC:Science LCC:Biology (General) |
| Subject Terms: | Plasmodium vivax, malaria, epidemiology, immunity, transmission, Papua New Guinea, Medicine, Science, Biology (General), QH301-705.5 |
| More Details: | The molecular force of blood-stage infection (molFOB) is a quantitative surrogate metric for malaria transmission at population level and for exposure at individual level. Relationships between molFOB, parasite prevalence and clinical incidence were assessed in a treatment-to-reinfection cohort, where P.vivax (Pv) hypnozoites were eliminated in half the children by primaquine (PQ). Discounting relapses, children acquired equal numbers of new P. falciparum (Pf) and Pv blood-stage infections/year (Pf-molFOB = 0–18, Pv-molFOB = 0–23) resulting in comparable spatial and temporal patterns in incidence and prevalence of infections. Including relapses, Pv-molFOB increased >3 fold (relative to PQ-treated children) showing greater heterogeneity at individual (Pv-molFOB = 0–36) and village levels. Pf- and Pv-molFOB were strongly associated with clinical episode risk. Yearly Pf clinical incidence rate (IR = 0.28) was higher than for Pv (IR = 0.12) despite lower Pf-molFOB. These relationships between molFOB, clinical incidence and parasite prevalence reveal a comparable decline in Pf and Pv transmission that is normally hidden by the high burden of Pv relapses. Clinical trial registration: ClinicalTrials.gov NCT02143934 |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2050-084X |
| Relation: | https://elifesciences.org/articles/23708; https://doaj.org/toc/2050-084X |
| DOI: | 10.7554/eLife.23708 |
| Access URL: | https://doaj.org/article/f964c3a008f041f0a3a67f96e82c6abc |
| Accession Number: | edsdoj.f964c3a008f041f0a3a67f96e82c6abc |
| Database: | Directory of Open Access Journals |
| ISSN: | 2050084X |
|---|---|
| DOI: | 10.7554/eLife.23708 |
| Published in: | eLife |
| Language: | English |