Bibliographic Details
| Title: |
Molecular Relationships between Bronchial Asthma and Hypertension as Comorbid Diseases |
| Authors: |
Bragina Elena Yu., Goncharova Irina A., Garaeva Anna F., Nemerov Evgeniy V., Babovskaya Anastasija A., Karpov Andrey B., Semenova Yulia V., Zhalsanova Irina Z., Gomboeva Densema E., Saik Olga V., Zolotareva Olga I., Ivanisenko Vladimir A., Dosenko Victor E., Hofestaedt Ralf, Freidin Maxim B. |
| Source: |
Journal of Integrative Bioinformatics, Vol 15, Iss 4, Pp 1055-68 (2018) |
| Publisher Information: |
De Gruyter, 2018. |
| Publication Year: |
2018 |
| Collection: |
LCC:Biotechnology |
| Subject Terms: |
comorbidity, bronchial asthma, hypertension, eqtl, snp, Biotechnology, TP248.13-248.65 |
| More Details: |
Comorbidity, a co-incidence of several disorders in an individual, is a common phenomenon. Their development is governed by multiple factors, including genetic variation. The current study was set up to look at associations between isolated and comorbid diseases of bronchial asthma and hypertension, on one hand, and single nucleotide polymorphisms associated with regulation of gene expression (eQTL), on the other hand. A total of 96 eQTL SNPs were genotyped in 587 Russian individuals. Bronchial asthma alone was found to be associated with rs1927914 (TLR4), rs1928298 (intergenic variant), and rs1980616 (SERPINA1); hypertension alone was found to be associated with rs11065987 (intergenic variant); rs2284033 (IL2RB), rs11191582 (NT5C2), and rs11669386 (CARD8); comorbidity between asthma and hypertension was found to be associated with rs1010461 (ANG/RNASE4), rs7038716, rs7026297 (LOC105376244), rs7025144 (intergenic variant), and rs2022318 (intergenic variant). The results suggest that genetic background of comorbidity of asthma and hypertension is different from genetic backgrounds of both diseases manifesting isolated. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1613-4516 |
| Relation: |
https://doaj.org/toc/1613-4516 |
| DOI: |
10.1515/jib-2018-0052 |
| Access URL: |
https://doaj.org/article/f958540e670b4ea0a8ee0a4e50e3a860 |
| Accession Number: |
edsdoj.f958540e670b4ea0a8ee0a4e50e3a860 |
| Database: |
Directory of Open Access Journals |
