Bibliographic Details
| Title: |
B Cells as Prognostic Biomarker After Surgery for Colorectal Liver Metastases |
| Authors: |
Joost Hof, Lydia Visser, Diederik J. Höppener, Pieter M. H. Nierop, Miente M. Terpstra, Annette S. H. Gouw, Dirk J. Grünhagen, Cornelis Verhoef, Rolf H. Sijmons, Koert P. de Jong, Klaas Kok |
| Source: |
Frontiers in Oncology, Vol 10 (2020) |
| Publisher Information: |
Frontiers Media S.A., 2020. |
| Publication Year: |
2020 |
| Collection: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: |
colorectal liver metastases, cancer, genetics, RNA sequencing, B cells, immunohistochemistry, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: |
Background: The aim of this study was to identify more accurate variables to improve prognostication of individual patients with colorectal liver metastases (CRLM). Clinicopathological characteristics only partly explain the large range in survival rates.Methods: MessengerRNA expression profiles of resected CRLM of two patient groups were analysed by mRNA sequencing: poor survivors (death from recurrent disease 60 months after surgery). Tumour and adjacent liver parenchyma samples were analysed.Results: MessengerRNA expression profiling of the tumour samples identified 77 genes that were differentially expressed between the two survival groups at a False Discovery Rate (FDR) |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2234-943X |
| Relation: |
https://www.frontiersin.org/article/10.3389/fonc.2020.00249/full; https://doaj.org/toc/2234-943X |
| DOI: |
10.3389/fonc.2020.00249 |
| Access URL: |
https://doaj.org/article/f940bda3b01745c59d98154ff7af8a56 |
| Accession Number: |
edsdoj.f940bda3b01745c59d98154ff7af8a56 |
| Database: |
Directory of Open Access Journals |
