Bibliographic Details
| Title: |
Abnormalities of early folliculogenesis and serum anti-Müllerian hormone in chinese patients with polycystic ovary syndrome |
| Authors: |
Juan Du, Xiangyan Ruan, Fengyu Jin, Yanglu Li, Jiaojiao Cheng, Muqing Gu, Alfred Otto Mueck |
| Source: |
Journal of Ovarian Research, Vol 14, Iss 1, Pp 1-7 (2021) |
| Publisher Information: |
BMC, 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Gynecology and obstetrics |
| Subject Terms: |
PCOS, Early folliculogenesis, Follicle density, AMH, Gynecology and obstetrics, RG1-991 |
| More Details: |
Abstract Purpose To investigate abnormalities of early folliculogenesis and Anti-Müllerian hormone (AMH) concentrations in polycystic ovary syndrome (PCOS) patients, and to analyze the association between AMH and early-stage follicle densities (FD). Methods A total of 175 patients underwent ovarian tissue cryopreservation in the first official cryobank in China, of which 16 patients aged 30–40 years old were diagnosed with endometrial cancer (all without initial chemo/radiotherapy), including 5 patients with concurrent PCOS and the other 11 patients without. We obtained standard cortical biopsies to measure FD using calcein staining. Blood samples were collected before cryopreservation to evaluate AMH concentrations. Results PCOS showed nearly three times the primordial and primary FD than NPCOS (P = 0.027), as well as more secondary preantral follicles (P = 0.002). A significantly higher proportion of secondary preantral follicles and a lower proportion of primordial and primary follicles were observed in PCOS (P = 0.01). Furthermore, the AMH concentration in PCOS was four times higher than that in NPCOS (P = 0.003), which is significantly correlated with primordial and primary follicle densities (r = 0.855, P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1757-2215 |
| Relation: |
https://doaj.org/toc/1757-2215 |
| DOI: |
10.1186/s13048-021-00786-0 |
| Access URL: |
https://doaj.org/article/af8caa27ca3744929aa28d823c2ad739 |
| Accession Number: |
edsdoj.f8caa27ca3744929aa28d823c2ad739 |
| Database: |
Directory of Open Access Journals |
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