Bibliographic Details
| Title: |
Ingenious Fabrication of Ag-Filled Porous Anodic Alumina Films as Powerful SERS Substrates for Efficient Detection of Biological and Organic Molecules |
| Authors: |
Chih-Yi Liu, Rahul Ram, Rahim Bakash Kolaru, Anindya Sundar Jana, Annada Sankar Sadhu, Cheng-Shane Chu, Yi-Nan Lin, Bhola Nath Pal, Shih-Hsin Chang, Sajal Biring |
| Source: |
Biosensors, Vol 12, Iss 10, p 807 (2022) |
| Publisher Information: |
MDPI AG, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Biotechnology |
| Subject Terms: |
surface-enhanced Raman scattering, SERS, silver nanoparticles, anodic alumina, organic molecule detection, biomolecule detection, Biotechnology, TP248.13-248.65 |
| More Details: |
Surface-enhanced Raman scattering (SERS) has been widely used to effectively detect various biological and organic molecules. This detection method needs analytes adsorbed onto a specific metal nanostructure, e.g., Ag-nanoparticles. A substrate containing such a structure (called SERS substrate) is user-friendly for people implementing the adsorption and subsequent SERS detection. Here, we report on powerful SERS substrates based on efficient fabrication of Ag-filled anodic aluminum oxide (AAO) films. The films contain many nanopores with small as-grown inter-pore gap of 15 nm. The substrates are created by electrochemically depositing silver into nanopores without an additional pore widening process, which is usually needed for conventional two-step AAO fabrication. The created substrates contain well-separated Ag-nanoparticles with quite a small inter-particle gap and a high number density (2.5 × 1010 cm−2). We use one-step anodization together with omitting additional pore widening to improve the throughput of substrate fabrication. Such substrates provide a low concentration detection limit of 10−11 M and high SERS enhancement factor of 1 × 106 for rhodamine 6G (R6G). The effective detection of biological and organic molecules by the substrate is demonstrated with analytes of adenine, glucose, R6G, eosin Y, and methylene blue. These results allow us to take one step further toward the successful commercialization of AAO-based SERS substrates. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2079-6374 |
| Relation: |
https://www.mdpi.com/2079-6374/12/10/807; https://doaj.org/toc/2079-6374 |
| DOI: |
10.3390/bios12100807 |
| Access URL: |
https://doaj.org/article/f8a5db0543ff4be39ae16b27bf817b39 |
| Accession Number: |
edsdoj.f8a5db0543ff4be39ae16b27bf817b39 |
| Database: |
Directory of Open Access Journals |
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