Academic Journal
Chronic use of inhaled corticosteroids in patients admitted for respiratory virus infections: a 6-year prospective multicenter study
| Title: | Chronic use of inhaled corticosteroids in patients admitted for respiratory virus infections: a 6-year prospective multicenter study |
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| Authors: | David Luque-Paz, Pierre Tattevin, Paul Loubet, François Bénézit, Vincent Thibault, Fabrice Lainé, Philippe Vanhems, Selilah Amour, Bruno Lina, Xavier Duval, Anne-Sophie L’Honneur, Nadhira Fidouh, Christine Vallejo, Sophie Alain, Florence Galtier, Vincent Foulongne, Gisèle Lagathu, Nezha Lenzi, Zineb Lesieur, Odile Launay, Stéphane Jouneau, the FLUVAC Study Group |
| Source: | Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022) |
| Publisher Information: | Nature Portfolio, 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Medicine LCC:Science |
| Subject Terms: | Medicine, Science |
| More Details: | Abstract Inhaled corticosteroids (ICS) have been associated with increased risk of pneumonia. Their impact on respiratory virus infections is unclear. We performed a post-hoc analysis of the FLUVAC cohort, a multicenter prospective cohort study of adults hospitalized with influenza-like illness (ILI) during six consecutive influenza seasons (2012–2018). All patients were tested for respiratory virus infection by multiplex PCR on nasopharyngeal swabs and/or bronchoalveolar lavage. Risk factors were identified by logistic regression analysis. Among the 2658 patients included, 537 (20.2%) were treated with ICS before admission, of whom 282 (52.5%, 282/537) tested positive for at least one respiratory virus. Patients on ICS were more likely to test positive for non-influenza respiratory viruses (25.1% vs. 19.5%, P = 0.004), especially for adenovirus (aOR 2.36, 95% CI 1.18–4.58), and respiratory syncytial virus (aOR 2.08, 95% CI 1.39–3.09). Complications were reported in 55.9% of patients on ICS (300/537), primarily pneumonia (171/535, 32%). Among patients on chronic ICS who tested positive for respiratory virus, 14.2% (40/282) were admitted to intensive care unit, and in-hospital mortality rate was 2.8% (8/282). Chronic use of ICS is associated with an increased risk of adenovirus or RSV infections in patients admitted for ILI. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-022-08089-0 |
| Access URL: | https://doaj.org/article/f8562029f08e4ef99ec479f7d1217130 |
| Accession Number: | edsdoj.f8562029f08e4ef99ec479f7d1217130 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 20452322 |
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| DOI: | 10.1038/s41598-022-08089-0 |
| Published in: | Scientific Reports |
| Language: | English |