Bibliographic Details
| Title: |
Cabergoline treatment promotes myocardial recovery in peripartum cardiomyopathy |
| Authors: |
Tobias J. Pfeffer, Julia H. Mueller, Lea Haebel, Sergej Erschow, Kuebra C. Yalman, Steven R. Talbot, Tobias Koenig, Dominik Berliner, Carolin Zwadlo, Michaela Scherr, Denise Hilfiker‐Kleiner, Johann Bauersachs, Melanie Ricke‐Hoch |
| Source: |
ESC Heart Failure, Vol 10, Iss 1, Pp 465-477 (2023) |
| Publisher Information: |
Wiley, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Diseases of the circulatory (Cardiovascular) system |
| Subject Terms: |
Peripartum cardiomyopathy (PPCM), Dopamine D2 receptor agonist, Bromocriptine, Cabergoline, Heart failure, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| More Details: |
Abstract Aims Peripartum cardiomyopathy (PPCM) is a rare heart disease, occurring in previously heart‐healthy women during the last month of pregnancy or the first months after delivery due to left ventricular (LV) systolic dysfunction. A common pathomechanistic pathway of PPCM includes increased oxidative stress and the subsequent generation of a cleaved prolactin fragment (16 kDa PRL), which promotes the onset of heart failure (HF) in a microRNA (miR)‐146a‐dependent manner. Inhibition of prolactin secretion with the dopamine D2 receptor (D2R) agonist bromocriptine combined with standard HF therapy supports cardiac recovery. This study examined whether treatment with the more selective D2R agonist cabergoline prevents HF development in an experimental PPCM mouse model and might be used as an alternative treatment regime for PPCM. Methods and results Postpartum (PP) female PPCM‐prone mice with a cardiomyocyte restricted STAT3‐deficiency (αMHC‐Cretg/+; Stat3fl/fl; CKO) were treated over two consecutive nursing periods with cabergoline (CKO Cab, 0.5 mg/kg/day) and were compared with bromocriptine treated CKO (CKO Br) and postpartum‐matched WT and CKO mice. Cabergoline treatment in CKO PP mice preserved cardiac function [fractional shortening (FS): CKO Cab: 34.5 ± 9.4% vs. CKO: 22.1 ± 9%, P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2055-5822 |
| Relation: |
https://doaj.org/toc/2055-5822 |
| DOI: |
10.1002/ehf2.14210 |
| Access URL: |
https://doaj.org/article/f8142b2460234ffe95bdde7d64e4c4b4 |
| Accession Number: |
edsdoj.f8142b2460234ffe95bdde7d64e4c4b4 |
| Database: |
Directory of Open Access Journals |
