| Title: |
CRIg on liver macrophages clears pathobionts and protects against alcoholic liver disease |
| Authors: |
Yi Duan, Huikuan Chu, Katharina Brandl, Lu Jiang, Suling Zeng, Nairika Meshgin, Eleni Papachristoforou, Josepmaria Argemi, Beatriz G. Mendes, Yanhan Wang, Hua Su, Weizhong Sun, Cristina Llorente, Tim Hendrikx, Xiao Liu, Mojgan Hosseini, Tatiana Kisseleva, David A. Brenner, Ramon Bataller, Prakash Ramachandran, Michael Karin, Wenxian Fu, Bernd Schnabl |
| Source: |
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021) |
| Publisher Information: |
Nature Portfolio, 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Science |
| Subject Terms: |
Science |
| More Details: |
CRIg is expressed on liver macrophages and binds Gram-positive bacteria to mediate phagocytosis, but it is not clear how its phagocytic functions contribute to liver homeostasis or disease. Here the authors report that ethanol impairs hepatic clearance of translocated pathobionts, via decreased hepatic CRIg, which facilitates progression of alcoholic liver disease. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-021-27385-3 |
| Access URL: |
https://doaj.org/article/f7ec4d70456c4928accc2ab2a0cc002c |
| Accession Number: |
edsdoj.f7ec4d70456c4928accc2ab2a0cc002c |
| Database: |
Directory of Open Access Journals |
