Academic Journal
Transcending frontiers in prostate cancer: the role of oncometabolites on epigenetic regulation, CSCs, and tumor microenvironment to identify new therapeutic strategies
| Title: | Transcending frontiers in prostate cancer: the role of oncometabolites on epigenetic regulation, CSCs, and tumor microenvironment to identify new therapeutic strategies |
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| Authors: | Giulia Ambrosini, Marco Cordani, Ali Zarrabi, Sergio Alcon-Rodriguez, Rosa M. Sainz, Guillermo Velasco, Pedro Gonzalez-Menendez, Ilaria Dando |
| Source: | Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-22 (2024) |
| Publisher Information: | BMC, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Medicine LCC:Cytology |
| Subject Terms: | Prostate cancer, Oncometabolites, Epigenetic alterations, Cancer stem cells (CSCs), Metabolic Enzymes, EMT, Medicine, Cytology, QH573-671 |
| More Details: | Abstract Prostate cancer, as one of the most prevalent malignancies in males, exhibits an approximate 5-year survival rate of 95% in advanced stages. A myriad of molecular events and mutations, including the accumulation of oncometabolites, underpin the genesis and progression of this cancer type. Despite growing research demonstrating the pivotal role of oncometabolites in supporting various cancers, including prostate cancer, the root causes of their accumulation, especially in the absence of enzymatic mutations, remain elusive. Consequently, identifying a tangible therapeutic target poses a formidable challenge. In this review, we aim to delve deeper into the implications of oncometabolite accumulation in prostate cancer. We center our focus on the consequential epigenetic alterations and impacts on cancer stem cells, with the ultimate goal of outlining novel therapeutic strategies. Graphical Abstract |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1478-811X |
| Relation: | https://doaj.org/toc/1478-811X |
| DOI: | 10.1186/s12964-023-01462-0 |
| Access URL: | https://doaj.org/article/f7de861908ba488998eaa45fa750eeaf |
| Accession Number: | edsdoj.f7de861908ba488998eaa45fa750eeaf |
| Database: | Directory of Open Access Journals |
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| ISSN: | 1478811X |
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| DOI: | 10.1186/s12964-023-01462-0 |
| Published in: | Cell Communication and Signaling |
| Language: | English |