Academic Journal
A comparative analysis of differentially expressed mRNAs, miRNAs and circRNAs provides insights into the key genes involved in the high-altitude adaptation of yaks
| Title: | A comparative analysis of differentially expressed mRNAs, miRNAs and circRNAs provides insights into the key genes involved in the high-altitude adaptation of yaks |
|---|---|
| Authors: | Qianyun Ge, Yongbo Guo, Wangshan Zheng, Yuan Cai, Xuebin Qi, Shengguo Zhao |
| Source: | BMC Genomics, Vol 22, Iss 1, Pp 1-13 (2021) |
| Publisher Information: | BMC, 2021. |
| Publication Year: | 2021 |
| Collection: | LCC:Biotechnology LCC:Genetics |
| Subject Terms: | Yak, Zaosheng cattle, Transcriptome, Hypoxia, Lung, Biotechnology, TP248.13-248.65, Genetics, QH426-470 |
| More Details: | Abstract Background Yaks that inhabit the Tibetan Plateau exhibit striking phenotypic and physiological differences from cattle and have adapted well to the extreme conditions on the plateau. However, the mechanisms used by these animals for the regulation of gene expression at high altitude are not fully understood. Results Here, we sequenced nine lung transcriptomes of yaks at altitudes of 3400, 4200 and 5000 m, and low-altitude Zaosheng cattle, which is a closely related species, served as controls. The analysis identified 21,764 mRNAs, 1377 circRNAs and 1209 miRNAs. By comparing yaks and cattle, 4975 mRNAs, 252 circRNAs and 75 miRNAs were identified differentially expressed. By comparing yaks at different altitudes, we identified 756 mRNAs, 64 circRNAs and 83 miRNAs that were differentially expressed (fold change ≥2 and P-value |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1471-2164 |
| Relation: | https://doaj.org/toc/1471-2164 |
| DOI: | 10.1186/s12864-021-08044-9 |
| Access URL: | https://doaj.org/article/df77f613490f441f8ac24f149493c5f5 |
| Accession Number: | edsdoj.f77f613490f441f8ac24f149493c5f5 |
| Database: | Directory of Open Access Journals |
| Full text is not displayed to guests. | Login for full access. |
| ISSN: | 14712164 |
|---|---|
| DOI: | 10.1186/s12864-021-08044-9 |
| Published in: | BMC Genomics |
| Language: | English |