Bibliographic Details
| Title: |
Factors affecting free vancomycin concentration and target attainment of free area under the concentration-time curve |
| Authors: |
Toshiharu Urakami, Yusuke Oka, Takashi Matono, Yosuke Aoki |
| Source: |
Journal of Pharmaceutical Health Care and Sciences, Vol 11, Iss 1, Pp 1-7 (2025) |
| Publisher Information: |
BMC, 2025. |
| Publication Year: |
2025 |
| Collection: |
LCC:Therapeutics. Pharmacology
LCC:Pharmacy and materia medica |
| Subject Terms: |
Vancomycin, Protein binding rate, Therapeutic drug monitoring, Area under the concentration-time curve, Free area under the concentration-time curve, Hyper-proteinemia, Therapeutics. Pharmacology, RM1-950, Pharmacy and materia medica, RS1-441 |
| More Details: |
Abstract Background It has been reported that the protein binding rate of vancomycin (VCM) varies among individual patients. So, the authors investigated relevant factors that may affect free VCM concentration and target attainment of free area under the concentration-time curve (fAUC). Methods Thirty-nine patients were included. Multiple regression analysis was performed to determine the valuable factors in the free VCM concentration, and the target attainment of area under the concentration-time curve (AUC) 400–600 mg・h/L and fAUC200-300 mg・h/L was calculated. Results We found total protein was significant covariate for free VCM. Among 18 patients who were investigated for AUC and fAUC estimation, 9 patients (50.0%) and 12 patients (66.7%) reached AUC > 600 mg・h/L, and fAUC > 300 mg・h/L (p = 0.310), respectively. Conclusions Total protein is a significant predictor for free VCM estimation. And the fAUC-guided TDM for VCM TDM may contribute to more strict dosing than the AUC-guided TDM in hyper- or hypo-proteinemic population. Trial registration Retrospectively registered. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2055-0294 |
| Relation: |
https://doaj.org/toc/2055-0294 |
| DOI: |
10.1186/s40780-025-00419-4 |
| Access URL: |
https://doaj.org/article/acf77590857c4f098c82ad3f6b32dd0b |
| Accession Number: |
edsdoj.f77590857c4f098c82ad3f6b32dd0b |
| Database: |
Directory of Open Access Journals |
