Geneti c Traits of Brachiocephalic Atherosclerosis
| Title: | Geneti c Traits of Brachiocephalic Atherosclerosis |
|---|---|
| Authors: | A. F. Nurimanshin, R. R. Bogdanov, P. I. Mironov, A. A. Khusaenova |
| Source: | Креативная хирургия и онкология, Vol 11, Iss 4, Pp 293-299 (2021) |
| Publisher Information: | Bashkir State Medical University, 2021. |
| Publication Year: | 2021 |
| Collection: | LCC:Surgery LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: | systemic atherosclerosis, renin-angiotensin system, genotype, coronary heart disease, brachiocephalic vessels, morbid genetic predisposition, allele, genetic polymorphism, Surgery, RD1-811, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: | Background. According to the World Health Organization, the atherosclerosis development depends on the quality of life and lifestyle (60 %), genetic (20 %), environmental factors (10 %) and quality of medical aid (5 %). The routes to defeat atherosclerosis generally and certain systemic enzyme disorders in particular pertain in research into the population genetic predispositions to this pathology.Materials and methods. A comparative study of genetic predispositions to malignant brachiocephalic atherosclerosis analysed the renin—angiotensin system gene association in 60 patients. Th e renin—angiotensin system allelic and polymorphic loci haplotype frequencies have been determined.Results and discussion. Patients with atherosclerotic brachiocephalic vascular lesions revealed a statistically significant frequency of the AGT gene’s allele C involved in coronary heart disease development.Conclusion. Th e study suggests a putative involvement of the angiotensinogen system genes in mediating the development of brachiocephalic atherosclerosis and coronary heart disease |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English Russian |
| ISSN: | 2076-3093 2307-0501 |
| Relation: | https://www.surgonco.ru/jour/article/view/631; https://doaj.org/toc/2076-3093; https://doaj.org/toc/2307-0501 |
| DOI: | 10.24060/2076-3093-2021-11-4-293-299 |
| Access URL: | https://doaj.org/article/ef7362f3688e435fbb3fa77cd0ef8356 |
| Accession Number: | edsdoj.f7362f3688e435fbb3fa77cd0ef8356 |
| Database: | Directory of Open Access Journals |
| ISSN: | 20763093 23070501 |
|---|---|
| DOI: | 10.24060/2076-3093-2021-11-4-293-299 |
| Published in: | Креативная хирургия и онкология |
| Language: | English Russian |