Health impacts of new‐onset diabetes in women post‐gestational diabetes mellitus: Insights from Hong Kong's territory‐wide data
| Title: | Health impacts of new‐onset diabetes in women post‐gestational diabetes mellitus: Insights from Hong Kong's territory‐wide data |
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| Authors: | Xinge Zhang, Hongjiang Wu, Eric SH Lau, Baoqi Fan, Kit Ying Tsoi, Claudia HT Tam, Aimin Yang, Mai Shi, Elaine Chow, Alice PS Kong, Juliana CN Chan, Wing Hung Tam, Andrea OY Luk, Ronald CW Ma |
| Source: | Journal of Diabetes Investigation, Vol 15, Iss 6, Pp 772-781 (2024) |
| Publisher Information: | Wiley, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Diseases of the endocrine glands. Clinical endocrinology |
| Subject Terms: | Gestational diabetes mellitus, Public health, Cardiovascular disease, Population attributable fraction, Kidney complications, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| More Details: | ABSTRACT Aims/Introduction To determine the population health burden attributable to the development of diabetes among women with a history of gestational diabetes mellitus (GDM). Materials and Methods We conducted a retrospective analysis of women with a history of GDM attending the Hong Kong Hospital Authority between 2000 and 2019. The time‐varying population attributable fraction was calculated. Results A total of 76,181 women with a history of gestational diabetes mellitus were included, 6,606 of them developed diabetes during a median follow‐up of 8.6 years. The respective hazard ratios (95% confidence interval) among women with GDM who developed diabetes vs those with GDM only were 2.8 (2.2, 3.7) for cardiovascular disease (CVD), 4.8 (3.0, 7.7) for end‐stage kidney disease (ESKD), 2.2 (1.9, 2.6) for infection‐related hospitalization, and 1.8 (1.3, 2.4) for all‐cause mortality. The development of diabetes was associated with 1.3 (0.8, 1.7), 0.6 (0.3, 0.8), 3.2 (2.4, 4.0), and 0.5 (0.2, 0.9) additional incident cases per 1,000 person‐years, accounting for 24.0% (13.2%, 35.9%), 42.0% (22.5%, 58.8%), 10.8% (7.1%, 14.9%), and 6.0% (−3.1%, 16.1%) of absolute number of CVD, ESKD, infection‐related hospitalization, and all‐cause mortality over 20 years after GDM, respectively. Conclusions Diabetes is a significant contributor to the population health burden of some clinical outcomes in women with a history of gestational diabetes mellitus, but other risk factors need to be considered. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2040-1124 2040-1116 |
| Relation: | https://doaj.org/toc/2040-1116; https://doaj.org/toc/2040-1124 |
| DOI: | 10.1111/jdi.14167 |
| Access URL: | https://doaj.org/article/f70afa538080487d9ce21fb4fab7238b |
| Accession Number: | edsdoj.f70afa538080487d9ce21fb4fab7238b |
| Database: | Directory of Open Access Journals |
| ISSN: | 20401124 20401116 |
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| DOI: | 10.1111/jdi.14167 |
| Published in: | Journal of Diabetes Investigation |
| Language: | English |