Bibliographic Details
| Title: |
Memory CD4+ T-Cell Lymphocytic Angiopathy in Fatal Forms of COVID-19 Pulmonary Infection |
| Authors: |
Amélie Guihot, Isabelle Plu, Cathia Soulié, Alice Rousseau, Cecilia Nakid-Cordero, Karim Dorgham, Christophe Parizot, Elena Litvinova, Julien Mayaux, Isabelle Malet, Paul Quentric, Béhazine Combadière, Christophe Combadière, Olivia Bonduelle, Lucille Adam, Pierre Rosenbaum, Alexandra Beurton, Patrice Hémon, Patrice Debré, Vincent Vieillard, Brigitte Autran, Danielle Seilhean, Frédéric Charlotte, Anne-Geneviève Marcelin, Guy Gorochov, Charles-Edouard Luyt |
| Source: |
Frontiers in Immunology, Vol 13 (2022) |
| Publisher Information: |
Frontiers Media S.A., 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Immunologic diseases. Allergy |
| Subject Terms: |
COVID-19, T cell responses, Broncho-alveolar lavage (BAL), Autopsia, Vasculitis, Immunologic diseases. Allergy, RC581-607 |
| More Details: |
The immunopathological pulmonary mechanisms leading to Coronavirus Disease (COVID-19)-related death in adults remain poorly understood. Bronchoalveolar lavage (BAL) and peripheral blood sampling were performed in 74 steroid and non-steroid-treated intensive care unit (ICU) patients (23–75 years; 44 survivors). Peripheral effector SARS-CoV-2-specific T cells were detected in 34/58 cases, mainly directed against the S1 portion of the spike protein. The BAL lymphocytosis consisted of T cells, while the mean CD4/CD8 ratio was 1.80 in non-steroid- treated patients and 1.14 in steroid-treated patients. Moreover, strong BAL SARS-CoV-2 specific T-cell responses were detected in 4/4 surviving and 3/3 non-surviving patients. Serum IFN-γ and IL-6 levels were decreased in steroid-treated patients when compared to non-steroid treated patients. In the lung samples from 3 (1 non-ICU and 2 ICU) additional deceased cases, a lymphocytic memory CD4 T-cell angiopathy colocalizing with SARS-CoV-2 was also observed. Taken together, these data show that disease severity occurs despite strong antiviral CD4 T cell-specific responses migrating to the lung, which could suggest a pathogenic role for perivascular memory CD4 T cells upon fatal COVID-19 pneumonia. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1664-3224 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fimmu.2022.844727/full; https://doaj.org/toc/1664-3224 |
| DOI: |
10.3389/fimmu.2022.844727 |
| Access URL: |
https://doaj.org/article/f7014cec160b4152aeb3363be24cbbc0 |
| Accession Number: |
edsdoj.f7014cec160b4152aeb3363be24cbbc0 |
| Database: |
Directory of Open Access Journals |
