Bibliographic Details
| Title: |
Static Magnetic Fields Regulate T-Type Calcium Ion Channels and Mediate Mesenchymal Stem Cells Proliferation |
| Authors: |
Haokaifeng Wu, Chuang Li, Muqaddas Masood, Zhen Zhang, Esther González-Almela, Alvaro Castells-Garcia, Gaoyang Zou, Xiaoduo Xu, Luqin Wang, Guoqing Zhao, Shengyong Yu, Ping Zhu, Bo Wang, Dajiang Qin, Jing Liu |
| Source: |
Cells, Vol 11, Iss 15, p 2460 (2022) |
| Publisher Information: |
MDPI AG, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Cytology |
| Subject Terms: |
static magnetic field, mesenchymal stem cell, T-type calcium ion channel, MAPK signaling pathway, Cytology, QH573-671 |
| More Details: |
The static magnetic fields (SMFs) impact on biological systems, induce a variety of biological responses, and have been applied to the clinical treatment of diseases. However, the underlying mechanisms remain largely unclear. In this report, by using human mesenchymal stem cells (MSCs) as a model, we investigated the biological effect of SMFs at a molecular and cellular level. We showed that SMF exposure promotes MSC proliferation and activates the expression of transcriptional factors such as FOS (Fos Proto-Oncogene, AP-1 Transcription Factor Subunit) and EGR1 (Early Growth Response 1). In addition, the expression of signal-transduction proteins p-ERK1/2 and p-JNK oscillate periodically with SMF exposure time. Furthermore, we found that the inhibition of the T-type calcium ion channels negates the biological effects of SMFs on MSCs. Together, we revealed that the SMFs regulate T-type calcium ion channels and mediate MSC proliferation via the MAPK signaling pathways. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2073-4409 |
| Relation: |
https://www.mdpi.com/2073-4409/11/15/2460; https://doaj.org/toc/2073-4409 |
| DOI: |
10.3390/cells11152460 |
| Access URL: |
https://doaj.org/article/acf6c97613e3415588a72786ca17278d |
| Accession Number: |
edsdoj.f6c97613e3415588a72786ca17278d |
| Database: |
Directory of Open Access Journals |
|
Full text is not displayed to guests. |
Login for full access.
|
