Bibliographic Details
| Title: |
CSF metabolic and proteomic profiles in patients prodromal for psychosis. |
| Authors: |
Jeffrey T-J Huang, F Markus Leweke, Tsz M Tsang, Dagmar Koethe, Laura Kranaster, Christoph W Gerth, Sonja Gross, Daniela Schreiber, Stephan Ruhrmann, Frauke Schultze-Lutter, Joachim Klosterkötter, Elaine Holmes, Sabine Bahn |
| Source: |
PLoS ONE, Vol 2, Iss 8, p e756 (2007) |
| Publisher Information: |
Public Library of Science (PLoS), 2007. |
| Publication Year: |
2007 |
| Collection: |
LCC:Medicine
LCC:Science |
| Subject Terms: |
Medicine, Science |
| More Details: |
BACKGROUND: The initial prodromal state of psychosis (IPS) is defined as an early disease stage prior to the onset of overt psychosis characterized by sub-threshold or more unspecific psychiatric symptoms. Little is known regarding the biochemical changes during this period. METHODOLOGY/PRINCIPAL FINDINGS: We investigated the metabolic/proteomic profiles of cerebrospinal fluid (CSF) of first-onset drug naïve paranoid schizophrenia patients (n = 54) and individuals presenting with initial prodromal symptoms (n = 24), alongside healthy volunteers (n = 70) using proton nuclear magnetic resonance ((1)H-NMR) spectroscopy and surface enhanced laser desorption ionization (SELDI) mass spectrometry, respectively. Partial least square discriminant analysis (PLS-DA) showed that 36%/29% of IPS patients displayed proteomic/metabolic profiles characteristic of first-onset, drug naïve schizophrenia, i.e., changes in levels of glucose and lactate as well as changes in a VGF-derived peptide (VGF23-62) and transthyretin protein concentrations. However, only 29% (n = 7) of the investigated IPS patients (who to date have been followed up for up to three years) have so far received a diagnosis of schizophrenia. The presence of biochemical alterations in the IPS group did not correlate with the risk to develop schizophrenia. CONCLUSIONS/SIGNIFICANCE: Our results imply that schizophrenia-related biochemical disease processes can be traced in CSF of prodromal patients. However, the biochemical disturbances identified in IPS patients, at least when measured at a single time point, may not be sufficient to predict clinical outcome. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1932-6203 |
| Relation: |
http://europepmc.org/articles/PMC1942084?pdf=render; https://doaj.org/toc/1932-6203 |
| DOI: |
10.1371/journal.pone.0000756 |
| Access URL: |
https://doaj.org/article/f6a9aae8d688456fb433348f6c376a7d |
| Accession Number: |
edsdoj.f6a9aae8d688456fb433348f6c376a7d |
| Database: |
Directory of Open Access Journals |
