Academic Journal
Chest CT Airway and Vascular Measurements in Females with COPD or Long-COVID
| Title: | Chest CT Airway and Vascular Measurements in Females with COPD or Long-COVID |
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| Authors: | Harkiran K. Kooner, Paulina V. Wyszkiewicz, Alexander M. Matheson, Marrissa J. McIntosh, Mohamed Abdelrazek, Inderdeep Dhaliwal, J. Michael Nicholson, Miranda Kirby, Sarah Svenningsen, Grace Parraga |
| Source: | COPD, Vol 21, Iss 1 (2024) |
| Publisher Information: | Taylor & Francis Group, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Diseases of the respiratory system |
| Subject Terms: | CT, COVID-19, long-COVID, coronavirus disease, COPD, pulmonary airways, Diseases of the respiratory system, RC705-779 |
| More Details: | Chest CT provides a way to quantify pulmonary airway and vascular tree measurements. In patients with COPD, CT airway measurement differences in females are concomitant with worse quality-of-life and other outcomes. CT total airway count (TAC), airway lumen area (LA), and wall thickness (WT) also differ in females with long-COVID. Our objective was to evaluate CT airway and pulmonary vascular and quality-of-life measurements in females with COPD as compared to ex-smokers and patients with long-COVID. Chest CT was acquired 3-months post-COVID-19 infection in females with long-COVID for comparison with the same inspiratory CT in female ex-smokers and COPD patients. TAC, LA, WT, and pulmonary vascular measurements were quantified. Linear regression models were adjusted for confounders including age, height, body-mass-index, lung volume, pack-years and asthma diagnosis. Twenty-one females (53 ± 14 years) with long-COVID, 17 female ex-smokers (69 ± 9 years) and 13 female COPD (67 ± 6 years) patients were evaluated. In the absence of differences in quality-of-life scores, females with long-COVID reported significantly different LA (p = 0.006) compared to ex-smokers but not COPD (p = 0.7); WT% was also different compared to COPD (p = 0.009) but not ex-smokers (p = 0.5). In addition, there was significantly greater pulmonary small vessel volume (BV5) in long-COVID as compared to female ex-smokers (p = 0.045) and COPD (p = 0.003) patients and different large (BV10) vessel volume as compared to COPD (p = 0.03). In females with long-COVID and highly abnormal quality-of-life scores, there was CT evidence of airway remodelling, similar to ex-smokers and patients with COPD, but there was no evidence of pulmonary vascular remodelling.Clinical Trial Registration: www.clinicaltrials.gov NCT05014516 and NCT02279329 |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 15412555 1541-2563 1541-2555 |
| Relation: | https://doaj.org/toc/1541-2555; https://doaj.org/toc/1541-2563 |
| DOI: | 10.1080/15412555.2024.2394129 |
| Access URL: | https://doaj.org/article/f6800977c9644b15989bffbb6fdc877e |
| Accession Number: | edsdoj.f6800977c9644b15989bffbb6fdc877e |
| Database: | Directory of Open Access Journals |
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| ISSN: | 15412555 15412563 |
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| DOI: | 10.1080/15412555.2024.2394129 |
| Published in: | COPD |
| Language: | English |