Reducing Caloric Intake Prevents Ischemic Injury and Myocardial Dysfunction and Affects Anesthetic Cardioprotection in Type 2 Diabetic Rats
| Title: | Reducing Caloric Intake Prevents Ischemic Injury and Myocardial Dysfunction and Affects Anesthetic Cardioprotection in Type 2 Diabetic Rats |
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| Authors: | Charissa E. van den Brom, Christa Boer, Rob F. P. van den Akker, Stephan A. Loer, R. Arthur Bouwman |
| Source: | Journal of Diabetes Research, Vol 2017 (2017) |
| Publisher Information: | Hindawi Limited, 2017. |
| Publication Year: | 2017 |
| Collection: | LCC:Diseases of the endocrine glands. Clinical endocrinology |
| Subject Terms: | Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| More Details: | Background. Type 2 diabetes mellitus (T2DM) increases the risk of myocardial ischemia, followed by increased perioperative risk of cardiovascular morbidity. We investigated whether reducing caloric intake reduces ischemic injury and myocardial dysfunction and affects the protective effects of the volatile anesthetic sevoflurane in diet-induced T2DM rats. Methods. Rats received a western (WD) or control diet (CD). Caloric intake was reduced by reversing WD-fed rats to CD. Myocardial function was determined with echocardiography. After 8 weeks of diet feeding, myocardial infarction was induced and the effect of sevoflurane was studied on myocardial function and ischemia/reperfusion injury. Results. WD-feeding resulted in a mild T2DM phenotype and myocardial dysfunction. Sevoflurane further impaired systolic function in WD-fed rats. Unexpectedly, WD-feeding reduced infarct size compared to CD-feeding. Sevoflurane reduced infarct size in CD-fed rats; however it enlarged infarct size in WD-fed rats. Caloric reduction restored myocardial dysfunction and the protective effect of sevoflurane against ischemia compared to WD-fed rats, whereas the protective effects of WD-feeding persisted. Conclusion. Caloric reduction restored the T2DM phenotype and myocardial function, while the cardioprotective properties of WD-feeding or sevoflurane persisted. Our data suggest that reducing caloric intake in T2DM might be a possible intervention to reduce perioperative risk of cardiovascular morbidity. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2314-6745 2314-6753 |
| Relation: | https://doaj.org/toc/2314-6745; https://doaj.org/toc/2314-6753 |
| DOI: | 10.1155/2017/4126820 |
| Access URL: | https://doaj.org/article/df660f6603594ef7843cec70b4d169c2 |
| Accession Number: | edsdoj.f660f6603594ef7843cec70b4d169c2 |
| Database: | Directory of Open Access Journals |
| ISSN: | 23146745 23146753 |
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| DOI: | 10.1155/2017/4126820 |
| Published in: | Journal of Diabetes Research |
| Language: | English |