Bibliographic Details
| Title: |
Perioperative Low-Dose Ketamine for Postoperative Pain Management in Spine Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| Authors: |
Lijin Zhou, Honghao Yang, Yong Hai, Yunzhong Cheng |
| Source: |
Pain Research and Management, Vol 2022 (2022) |
| Publisher Information: |
Hindawi Limited, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Medicine (General) |
| Subject Terms: |
Medicine (General), R5-920 |
| More Details: |
Objective. Although low-dose ketamine has been shown to be generally beneficial in terms of pain control in a variety of major surgery, there is no consensus regarding the effectiveness of supplemental ketamine analgesic use exclusively in spine surgery. The objective of this systematic review and meta-analysis of randomized controlled trials (RCTs) was to assess the efficacy and safety of perioperative low-dose ketamine for pain management and analgesic consumption in patients undergoing spine surgery. Methods. A comprehensive literature search was performed for relevant studies using PubMed, EMBASE, Web of Science, and Cochrane Library. Patients who received perioperative low-dose ketamine were compared to the control group in terms of postoperative pain intensity, opioid consumption, and adverse events. Patients were further categorized by ages and administration times for subgroup analysis. Results. A total of 30 RCTs comprising 1,865 patients undergoing elective spine surgery were included. Significantly lower pain intensity and less opioid consumption at 12 h, 24 h, and 48 h postoperatively and lower incidence of postoperative nausea and vomiting (PONV) were observed in the ketamine group (all P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1918-1523 |
| Relation: |
https://doaj.org/toc/1918-1523 |
| DOI: |
10.1155/2022/1507097 |
| Access URL: |
https://doaj.org/article/f6454513dc0748b5a67c828974e2413d |
| Accession Number: |
edsdoj.f6454513dc0748b5a67c828974e2413d |
| Database: |
Directory of Open Access Journals |
