A Combined Cytomorphological and Immunocytochemical Approach in the Diagnosis of Cancers of Unknown Primary Origin
| Title: | A Combined Cytomorphological and Immunocytochemical Approach in the Diagnosis of Cancers of Unknown Primary Origin |
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| Authors: | S Nafeesa Banu, Neeliah Siddaraju, Surendra Kumar Verma, Arun Alexander |
| Source: | National Journal of Laboratory Medicine, Vol 10, Iss 1, Pp PO46-PO51 (2021) |
| Publisher Information: | JCDR Research and Publications Pvt. Ltd., 2021. |
| Publication Year: | 2021 |
| Collection: | LCC:Microbiology LCC:Chemistry |
| Subject Terms: | fine needle aspiration cytology, immunocytochemistry, metastatic deposits, Microbiology, QR1-502, Chemistry, QD1-999 |
| More Details: | Introduction: Unknown Primary Cancers (UPCs) present a major diagnostic challenge to both clinicians and pathologists. Hence, there is a strong need to effectively diagnose these cases. Aim: To study the cytological features of metastatic deposits from UPCs and the role of appropriate immunomarkers in identifying the primary site. Materials and Methods: This was a prospective descriptive study conducted between December 2012 to December 2015 in the Department of Pathology in JIPMER, Puducherry, India. Patients presenting with suspicious nodal or other probable metastatic deposits were subjected to Fine Needle Aspiration Cytology (FNAC). Morphologic features were studied and provisional/differential diagnosis were made, following which whenever essential, Immunocytochemistry (ICC) using appropriate panels of immunomarkers was performed on smears or cell blocks. Only the cases with subsequent histological/clinicoradiological correlation were statistically analysed by Statistical Package for Social Sciences (SPSS version 16.0) software and the distribution of data was expressed in frequencies and percentages and the p-value |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2277-8551 2455-6882 |
| Relation: | http://www.njlm.net/articles/PDF/2451/44787_CE[Ra1_F(SHU)_PF1(AB_SHU)_PFA(SHU_AB)_PN(SHU).pdf; https://doaj.org/toc/2277-8551; https://doaj.org/toc/2455-6882 |
| DOI: | 10.7860/NJLM/2021/44787:2451 |
| Access URL: | https://doaj.org/article/f633123237384003a5aaa978964b118e |
| Accession Number: | edsdoj.f633123237384003a5aaa978964b118e |
| Database: | Directory of Open Access Journals |
| ISSN: | 22778551 24556882 |
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| DOI: | 10.7860/NJLM/2021/44787:2451 |
| Published in: | National Journal of Laboratory Medicine |
| Language: | English |