Bibliographic Details
| Title: |
LncMPEG1/miR-2c regulates exoskeleton biocalcification via engrailed in bivalve |
| Authors: |
Minxin Liang, Caixia Cai, Ziqi Ren, Zhiqing Li, Ronglian Huang, Qingheng Wang, Yongshan Liao, Chuangye Yang, Zhe Zheng |
| Source: |
Aquaculture Reports, Vol 40, Iss , Pp 102616- (2025) |
| Publisher Information: |
Elsevier, 2025. |
| Publication Year: |
2025 |
| Collection: |
LCC:Aquaculture. Fisheries. Angling |
| Subject Terms: |
Pinctada fucata martensii, Shell growth, LncMPEG1, miR-2c, Aquaculture. Fisheries. Angling, SH1-691 |
| More Details: |
LncRNAs and miRNAs has been reported to play important regulation roles in skeleton growth. This research elucidates the molecular interplay between long noncoding RNA LncMPEG1 and miRNA miR-2c in the biocalcification process of shell formation. The study establishes LncMPEG1 as a molecular sponge for miR-2c, modulating the expression of key biomineralization genes, including homeobox protein engrailed and matrix metalloproteases (MMPs). Utilizing miRanda prediction, interaction sites between miR-2c and LncMPEG1 were identified and validated through RNA immunoprecipitation and luciferase assays. In vivo overexpression of miR-2c suppressed engrailed and MMP expression, while miR-2c inhibition induced the opposite effect. Luciferase assays confirmed miR-2c's inhibitory effect on the 3′UTR of target genes (p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2352-5134 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S235251342500002X; https://doaj.org/toc/2352-5134 |
| DOI: |
10.1016/j.aqrep.2025.102616 |
| Access URL: |
https://doaj.org/article/f5fddc4a1daf434d94fe0794664b3561 |
| Accession Number: |
edsdoj.f5fddc4a1daf434d94fe0794664b3561 |
| Database: |
Directory of Open Access Journals |
