Sex difference in sympathetic nervous system activity and blood pressure in hypertensive patients

Bibliographic Details
Title:	Sex difference in sympathetic nervous system activity and blood pressure in hypertensive patients
Authors:	Chin‐Chou Huang, Chia‐Min Chung, Hsin‐Bang Leu, Po‐Hsun Huang, Tao‐Cheng Wu, Liang‐Yu Lin, Shing‐Jong Lin, Wen‐Harn Pan, Jaw‐Wen Chen
Source:	The Journal of Clinical Hypertension, Vol 23, Iss 1, Pp 137-146 (2021)
Publisher Information:	Wiley, 2021.
Publication Year:	2021
Collection:	LCC:Diseases of the circulatory (Cardiovascular) system
Subject Terms:	blood pressure, catecholamine, hypertension, sex, sympathetic nervous system activity, Diseases of the circulatory (Cardiovascular) system, RC666-701
More Details:	Abstract Increased sympathetic nervous system (SNS) activity leads to increased risk of cardiovascular morbidity and mortality. This study investigated whether there were sex differences in SNS activity among Chinese patients with hypertension. Ethnic Chinese non‐diabetic hypertensive patients aged 20–50 years were enrolled in Taiwan. A total of 970 hypertensive patients (41.0 ± 7.2 years) completed the study, 664 men and 306 women. They received comprehensive evaluations including office blood pressure (BP) measurement, 24‐h ambulatory BP monitoring, and 24‐h urine sampling assayed for catecholamine excretion. Compared to women, men were younger, had higher body mass index (BMI), office systolic BP (SBP), office diastolic BP (DBP), 24‐h ambulatory BP, and 24‐h urine catecholamine excretion. In men, 24‐h urine total catecholamine levels were correlated with 24‐h SBP (r = 0.103, p = .008) and 24‐h DBP (r = 0.083, p = .033). In women, however, there was no correlation between 24‐h urine total catecholamine levels and 24‐h ambulatory BP. Multivariate linear regression indicated that being male (β = 1.65, 95% confidence interval [CI] 0.01–3.29, p = .048) and 24‐h urine total catecholamine (β = 5.03, 95% CI 0.62–9.44, p = .025) were both independently associated with 24‐h SBP; being male was independently associated with 24‐h DBP (β = 3.55, 95% CI 2.26–4.85, p
Document Type:	article
File Description:	electronic resource
Language:	English
ISSN:	1751-7176 1524-6175
Relation:	https://doaj.org/toc/1524-6175; https://doaj.org/toc/1751-7176
DOI:	10.1111/jch.14098
Access URL:	https://doaj.org/article/f5e9069a5ea0499f8fa62b384783c6ff
Accession Number:	edsdoj.f5e9069a5ea0499f8fa62b384783c6ff
Database:	Directory of Open Access Journals

More Details
ISSN:	17517176 15246175
DOI:	10.1111/jch.14098
Published in:	The Journal of Clinical Hypertension
Language:	English