Bibliographic Details
| Title: |
Bioengineering in salivary gland regeneration |
| Authors: |
Maryam Hajiabbas, Claudia D’Agostino, Julia Simińska-Stanny, Simon D. Tran, Amin Shavandi, Christine Delporte |
| Source: |
Journal of Biomedical Science, Vol 29, Iss 1, Pp 1-24 (2022) |
| Publisher Information: |
BMC, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Medicine |
| Subject Terms: |
Salivary gland, Tissue engineering, Biomaterial, Cell culture models, Xerostomia, Medicine |
| More Details: |
Abstract Salivary gland (SG) dysfunction impairs the life quality of many patients, such as patients with radiation therapy for head and neck cancer and patients with Sjögren’s syndrome. Multiple SG engineering strategies have been considered for SG regeneration, repair, or whole organ replacement. An in-depth understanding of the development and differentiation of epithelial stem and progenitor cells niche during SG branching morphogenesis and signaling pathways involved in cell–cell communication constitute a prerequisite to the development of suitable bioengineering solutions. This review summarizes the essential bioengineering features to be considered to fabricate an engineered functional SG model using various cell types, biomaterials, active agents, and matrix fabrication methods. Furthermore, recent innovative and promising approaches to engineering SG models are described. Finally, this review discusses the different challenges and future perspectives in SG bioengineering. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1423-0127 |
| Relation: |
https://doaj.org/toc/1423-0127 |
| DOI: |
10.1186/s12929-022-00819-w |
| Access URL: |
https://doaj.org/article/f5d6959a84ff4af7b5bb0f77ecc1d12a |
| Accession Number: |
edsdoj.f5d6959a84ff4af7b5bb0f77ecc1d12a |
| Database: |
Directory of Open Access Journals |
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