Farnesyl diphosphate synthase is important for the maintenance of glioblastoma stemness
| Title: | Farnesyl diphosphate synthase is important for the maintenance of glioblastoma stemness |
|---|---|
| Authors: | Hee Yeon Kim, Dong Keon Kim, Seung-Hyun Bae, HyeRan Gwak, Ji Hoon Jeon, Jong Kwang Kim, Byung Il Lee, Hye Jin You, Dong Hoon Shin, Young-Ho Kim, Soo Youl Kim, Sung-Sik Han, Jin-Kyoung Shim, Ji-Hyun Lee, Seok-Gu Kang, Hyonchol Jang |
| Source: | Experimental and Molecular Medicine, Vol 50, Iss 10, Pp 1-12 (2018) |
| Publisher Information: | Nature Publishing Group, 2018. |
| Publication Year: | 2018 |
| Collection: | LCC:Medicine LCC:Biochemistry |
| Subject Terms: | Medicine, Biochemistry, QD415-436 |
| More Details: | Brain cancer: Enzyme target for potential therapy A drug that targets a key enzyme in aggressive brain cancer tumors could help tackle resistance to existing treatments. Glioblastoma is the most aggressive form of brain cancer and remains difficult to treat because the cancer cells can survive chemotherapy and radiotherapy. Certain cells within glioblastoma tumors have ‘stemness’ – unique stem cell-like metabolic characteristics that allow them to rapidly repair DNA damage and trigger relapse. Hyonchol Jang at the National Cancer Center in Goyang, South Korea and co-workers discovered that an enzyme called farnesyl diphosphate synthase (FDPS) helps maintain stemness in glioblastoma. The team then treated patient-derived glioblastoma cells with existing drugs known to inhibit FDPS. One such drug, which is already used to treat osteoporosis, inhibited the formation of secondary glioblastoma and may prove valuble in the treatment of brain cancer. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1226-3613 2092-6413 |
| Relation: | https://doaj.org/toc/1226-3613; https://doaj.org/toc/2092-6413 |
| DOI: | 10.1038/s12276-018-0166-2 |
| Access URL: | https://doaj.org/article/f5bde652b6794bac89129022c500c7fa |
| Accession Number: | edsdoj.f5bde652b6794bac89129022c500c7fa |
| Database: | Directory of Open Access Journals |
| ISSN: | 12263613 20926413 |
|---|---|
| DOI: | 10.1038/s12276-018-0166-2 |
| Published in: | Experimental and Molecular Medicine |
| Language: | English |