Bibliographic Details
| Title: |
Computational pharmacogenomic screen identifies drugs that potentiate the anti-breast cancer activity of statins |
| Authors: |
Jenna E. van Leeuwen, Wail Ba-Alawi, Emily Branchard, Jennifer Cruickshank, Wiebke Schormann, Joseph Longo, Jennifer Silvester, Peter L. Gross, David W. Andrews, David W. Cescon, Benjamin Haibe-Kains, Linda Z. Penn, Deena M. A. Gendoo |
| Source: |
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022) |
| Publisher Information: |
Nature Portfolio, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Science |
| Subject Terms: |
Science |
| More Details: |
Statins are promising for breast cancer therapy; dipyridamole can potentiate their effects, but is contraindicated in some cases. Here, the authors develop a pharmacogenomics pipeline to predict other compounds that potentiate statins, and validate the top candidates in cell line screens and 3D cultures. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-022-33144-9 |
| Access URL: |
https://doaj.org/article/f57984f909454f0787ee786ab65589d9 |
| Accession Number: |
edsdoj.f57984f909454f0787ee786ab65589d9 |
| Database: |
Directory of Open Access Journals |
